Cardio protective activities of n-hexane extract of desmodium velutinum stem on albino wister rat

 

Table Of Contents


Chapter ONE

INTRODUCTION

  • 1.1Introduction
  • 1.2Background of Study
  • 1.3Problem Statement
  • 1.4Objective of Study
  • 1.5Limitation of Study
  • 1.6Scope of Study
  • 1.7Significance of Study
  • 1.8Structure of the Research
  • 1.9Definition of Terms

Chapter TWO

LITERATURE REVIEW

  • 2.1Overview of Cardiovascular Diseases
  • 2.2Desmodium Velutinum: Botanical Description
  • 2.3Traditional Uses of Desmodium Velutinum
  • 2.4Phytochemical Composition of Desmodium Velutinum
  • 2.5Pharmacological Activities of Desmodium Velutinum
  • 2.6Previous Studies on the Cardio-protective Activities of Desmodium Velutinum
  • 2.7Mechanisms of Action of N-hexane Extracts
  • 2.8Animal Models in Cardiovascular Research
  • 2.9Methodologies for Extract Preparation
  • 2.10Dosage and Administration of N-hexane Extract

Chapter THREE

RESEARCH METHODOLOGY

  • 3.1Research Design
  • 3.2Sampling Techniques
  • 3.3Data Collection Methods
  • 3.4Data Analysis Procedures
  • 3.5Ethical Considerations
  • 3.6Validity and Reliability of Data
  • 3.7Statistical Tools Used
  • 3.8Study Variables

Chapter FOUR

DATA PRESENTATION AND ANALYSIS

  • 4.1Overview of Findings
  • 4.2Effects of N-hexane Extract on Blood Pressure
  • 4.3Impact on Lipid Profiles
  • 4.4Antioxidant Properties of the Extract
  • 4.5Histopathological Changes in Cardiac Tissues
  • 4.6Comparison with Standard Drugs
  • 4.7Adverse Effects and Safety Profile
  • 4.8Recommendations for Further Research

Chapter FIVE

SUMMARY, CONCLUSION AND RECOMMENDATIONS

  • 5.1Summary of Findings
  • 5.2Conclusions
  • 5.3Implications of the Study
  • 5.4Practical Applications
  • 5.5Recommendations for Practice

Project Abstract

<p> This study evaluates the cardio protactive effect of N-hexane extract of Desmodium Velutinum stem on albino wister rat. Rats used in this study were grouped into four and each group was fed differentely. Rats in group one, three, and four wre fed with the aid of a syringe without needle with 6ml of the lipoprotein food mixture containing 3.6g of the cow’s brain twice a day for seven days. Rats on group two was fed with only grower’s mash and water for seven days; rats in group three was later administered orally 2ml of dissolved vasoprin drug once in a day for 3 days. Rats in group four were also administered orally 0.5ml of the liquid drug extract of Desmodium Velutinum stem once a day for 3 days. During these three (3) days, the rats were given grower’s mash and water. After the feeding period, the rate fed with the cow’s brain showed a significant increases in the activities of marker enzymes such as creatine kinase (CK), creatine kinase MB (CKMB), Aspartatatranseaminase (AST), Alaninetransminase (ALT), and lactatedehydrogenase. This study shows that N-hexane extract of Desmodium Velutinum stem posses cardio protective effect on albino wister rats than the known drug (vasoprin) if only one can increase the dosage of the extract for a period of time. <br></p>

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