The effect of the ethanolic extract of anchomanes difformis (blume) on liver functions of adult wistar rats

 

Table Of Contents


Chapter ONE

INTRODUCTION

  • 1.1Introduction
  • 1.2Background of Study
  • 1.3Problem Statement
  • 1.4Objective of Study
  • 1.5Limitation of Study
  • 1.6Scope of Study
  • 1.7Significance of Study
  • 1.8Structure of the Research
  • 1.9Definition of Terms

Chapter TWO

LITERATURE REVIEW

  • 2.1Overview of Liver Functions
  • 2.2Review of Liver Anatomy and Physiology
  • 2.3Previous Studies on Liver Function Tests
  • 2.4Effects of Herbal Extracts on Liver Functions
  • 2.5Role of Antioxidants in Liver Health
  • 2.6Liver Diseases and Their Impact
  • 2.7Pharmacological Properties of Anchomanes difformis
  • 2.8Studies on the Ethanol Extract of Anchomanes difformis
  • 2.9Mechanisms of Action of Ethanol Extract on Liver
  • 2.10Gaps in Current Literature

Chapter THREE

RESEARCH METHODOLOGY

  • 3.1Research Design and Methodology
  • 3.2Selection of Sample Population
  • 3.3Preparation of the Ethanol Extract
  • 3.4Animal Model and Experimental Setup
  • 3.5Administration of the Extract
  • 3.6Data Collection Methods
  • 3.7Variables and Parameters Measured
  • 3.8Statistical Analysis Techniques

Chapter FOUR

DATA PRESENTATION AND ANALYSIS

  • 4.1Overview of Research Findings
  • 4.2Effects of Anchomanes difformis Extract on Liver Enzymes
  • 4.3Impact on Liver Function Tests
  • 4.4Histological Changes in Liver Tissues
  • 4.5Comparison with Control Group
  • 4.6Correlation Analysis of Data
  • 4.7Discussion on Results
  • 4.8Implications for Liver Health

Chapter FIVE

SUMMARY, CONCLUSION AND RECOMMENDATIONS

  • 5.1Summary of Findings
  • 5.2Conclusion
  • 5.3Contributions to Existing Knowledge
  • 5.4Recommendations for Future Research
  • 5.5Practical Applications of the Study

Project Abstract

<p> </p><div><p>This research was carried out to determine the effect of administration of <em>Achomanes Difformis (blume) </em>on liver functions in adult wistar rat, in which 20 adult wistar rats were purchased at the institute of advanced medical research and training (IMRAT), UCH, Ibadan. The rats were grouped into 4 in which there is a control group in which the rats were placed on normal diet and water. Other groups (A, B and C) were administered 300mg/kg/b.wt, 500mg/kg/b.wt and 700mg/kg/b.wt respectively. The herb was administered for duration of 14 days. Their cages were cleaned every day maintain proper hygiene. The rats were sacrificed immediately after two weeks of drug administration. From the result obtained, the administration of <em>Anchomanes difformis</em>&nbsp;has a hepatotoxic effect. It showed that there was an insignificant increase (p&gt;0.05) in the level of AST, ALT and ALP, and an insignificant decrease (p&gt;0.05) in the level of Total and Direct Bilirubin in the plasma at different dosage rate of the herb, when compared to the control group. The result demonstrates that the ingestion of <em>Anchomanes</em>&nbsp;<em>difformis </em>has a hepatotoxic effect in adult wistar rat.</p><p></p></div><h3></h3><br> <br><p></p>

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