The anti-inflammatory activity of crateva adansonii dichloromethane fraction

• <p> </p><p>Title page – – – – – -i</p><p>Approval page – – – – – -ii</p><p>Dedication – – – – – -iii</p><p>Acknowledgment – – – – – -iv</p><p>Abstract – – – – – -v</p><p>Table of Content – – – – – -vi</p><p><b>

Chapter ONE

INTRODUCTION

• </b></p><p>
• 1.0Introduction – – – – – -1</p><p>
• 1.1Crateva adansonii – – – – – -2</p><p>
• 1.2Research Aim &amp; Objectives – – – – – -2</p><p><b>

Chapter TWO

LITERATURE REVIEW

• </b></p><p>
• 2.1Definition of Inflammation – – – – – -3</p><p>2.
• 1.1What is Anti-inflammation? – – – – – -3</p><p>Types of Inflammation (Acute and Chronic) – – – -4</p><p>2.
• 1.2Steroid and non-steroidal anti-inflammatory drugs – – -5</p><p>2.
• 1.3Immune selective anti-inflammatory derivative – – -6</p><p>2.
• 1.4Pain – – – – – -7</p><p>2.
• 1.5Long effect of inflammation – – – – – -8</p><p>2.
• 1.6Ice Treatment of Inflammation – – – – – – 9</p><p>2.
• 1.7Nutritional sources of anti-inflammatory compounds – -9</p><p>
• 2.2Vascular event in inflammation- – – – – -9</p><p>2.
• 2.1Vasoconstriction – – – – – -10</p><p>2.
• 2.2Vasodilation – – – – – -11</p><p>2.
• 2.3Vascular permeability – – – – – -11</p><p>
• 2.3Cellular event – – – – – -14</p><p>2.
• 3.1Leukocytes migration as specific Hemoral/cellular immunity- – – – – -14</p><p>
• 2.4Mediators of inflammation – – – – – -17</p><p>2.
• 4.1Cell derived mediators of inflammation- – – – -18</p><p>2.
• 4.2Histamine – – – – – -19</p><p>2.
• 4.3Cytokines – – – – – -19</p><p>2.
• 4.4Serotonin (5-hydroxytryptamine)- – – – – -19</p><p>2.
• 4.5Platelet-Activating factor (PAF)- – – – – -20</p><p>2.
• 4.6Arachidonic Acid (AA – – – – – -20</p><p>2.
• 4.7Free radicals as mediators of inflammation- – – – -22</p><p>2.
• 4.8Nitric Acid (NO) – – – – – -23</p><p>2.
• 4.9Reactive Oxygen Species (ROS)- – – – – –</p><p><b>

Chapter THREE

RESEARCH METHODOLOGY

• </b></p><p>
• 3.1Materials, equipments and apparatus – – – – -25</p><p>
• 3.2Chemical, reagents and practical technique- – – -25</p><p>3.
• 2.1Methanol – – – – – -25</p><p>3.
• 2.2N-Hexane – – – – – -26</p><p>3.
• 2.3Ethyl acetate – – – – – -27</p><p>3.
• 2.4Dichloromethane – – – – – -28</p><p>
• 3.3Methodology – – – – – -29</p><p>3.
• 3.1Collection and preparation of plant- – – – – -29</p><p>3.
• 3.2Extraction and fractionation of plant materials- – – -29</p><p>
• 3.4Phytochemical Analysis – – – – – -30</p><p>
• 3.5Column chromatography – – – – – -32</p><p>
• 3.6Thin layer chromatography – – – – – -33</p><p>
• 3.7How to run TCL plate – – – – – -34</p><p><b>

Chapter FOUR

DATA PRESENTATION AND ANALYSIS

• </b></p><p>
• 4.0Experimental result – – – – – -38</p><p>
• 4.1Tabular and graphical representation of effect of anti-inflammatory effect of</p><p>Crateva adansonii dichloromethane extract- – – – -38</p><p>
• 4.2Phytochemical analysis of extract (result) – – – – -40</p><p><b>

Chapter FIVE

SUMMARY, CONCLUSION AND RECOMMENDATIONS

• </b></p><p>
• 5.0Discussion – – – – – -41</p><p>
• 5.1Conclusion – – – – – -41</p><p><b>REFERENCE – – – – – -42</b></p><p><b>APPENDIX I</b></p><p><b>APPENDIX II</b></p><p><b>APPENDIX III</b></p><p><b>APPENDIX IV</b></p><p><b>APPENDIX V</b></p> <br><p></p>