Study on the effect of allium ascalonicum ethanolic extract on liver functions: asp, alt, ast, direct and total bilirubin in adult wistar rats

 

Table Of Contents


Chapter ONE

INTRODUCTION

  • 1.1Introduction
  • 1.2Background of Study
  • 1.3Problem Statement
  • 1.4Objective of Study
  • 1.5Limitation of Study
  • 1.6Scope of Study
  • 1.7Significance of Study
  • 1.8Structure of the Research
  • 1.9Definition of Terms

Chapter TWO

LITERATURE REVIEW

  • 2.1Overview of Liver Functions
  • 2.2Allium Ascalonicum - Botanical Description
  • 2.3Liver Function Tests
  • 2.4Previous Studies on Allium Ascalonicum
  • 2.5Mechanism of Action of Allium Ascalonicum Extract
  • 2.6Liver Function Biomarkers
  • 2.7Effects of Allium Ascalonicum Extract on Liver Enzymes
  • 2.8Allium Ascalonicum Extract and Bilirubin Levels
  • 2.9Interaction of Allium Ascalonicum with Liver Functions
  • 2.10Summary of Literature Review

Chapter THREE

RESEARCH METHODOLOGY

  • 3.1Research Design and Methodology
  • 3.2Selection of Sample Population
  • 3.3Preparation of Allium Ascalonicum Ethanolic Extract
  • 3.4Animal Model Establishment
  • 3.5Administration of Allium Ascalonicum Extract
  • 3.6Liver Function Tests Protocol
  • 3.7Data Collection Methods
  • 3.8Statistical Analysis Plan

Chapter FOUR

DATA PRESENTATION AND ANALYSIS

  • 4.1Analysis of Liver Function Test Results
  • 4.2Effect of Allium Ascalonicum Extract on AST Levels
  • 4.3Effect of Allium Ascalonicum Extract on ALT Levels
  • 4.4Effect of Allium Ascalonicum Extract on Bilirubin Levels
  • 4.5Comparison of Liver Function Test Results
  • 4.6Interpretation of Findings
  • 4.7Discussion on the Mechanism of Action
  • 4.8Implications and Further Research

Chapter FIVE

SUMMARY, CONCLUSION AND RECOMMENDATIONS

  • 5.1Summary of Findings
  • 5.2Conclusion
  • 5.3Recommendations for Future Research
  • 5.4Practical Implications
  • 5.5Contribution to Existing Knowledge
  • 5.6Limitations of the Study
  • 5.7Research Contribution to Scientific Community
  • 5.8Final Remarks and Acknowledgments

Project Abstract

<p> The effect of ethanolic extract of Allium Ascallonicum was evaluated in male and female wistar rat during 14 days after the doses of (300, 500, 700)mg/kg body weight orally. Parameter evaluated include serum ASP, AST, ALT, direct bilirubin and Total bilirubin.20 wistar rats were divided into four groups with weight range of (150±20)g the group 1 is the control group ,group(ii,iii,iv) are treated with the extract in varying concentration of (300,500,700)mg/kg body weight respectively. The result showed that the groups treated with A. ascalonicum insignificantly increased in AST, ALT and ALP parameter by (p&gt;0.05) and insignificant decreased in direct and total bilirubin parameter by (p&gt;0.05). <br></p>

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