The effect of the ethanolic extract of anchomanes difformis (blume) on liver functions of adult wistar rats.

 

Table Of Contents


Chapter ONE

INTRODUCTION

  • 1.1Introduction
  • 1.2Background of the Study
  • 1.3Problem Statement
  • 1.4Objective of the Study
  • 1.5Limitation of Study
  • 1.6Scope of Study
  • 1.7Significance of Study
  • 1.8Structure of the Research
  • 1.9Definition of Terms

Chapter TWO

LITERATURE REVIEW

  • 2.1Overview of Liver Functions
  • 2.2Review of Previous Studies on Liver Health
  • 2.3Effects of Plant Extracts on Liver Functions
  • 2.4Anchomanes difformis (Blume) Plant Description
  • 2.5Chemical Composition of Anchomanes difformis Extract
  • 2.6Pharmacological Properties of Anchomanes difformis Extract
  • 2.7Liver Diseases and Their Impact
  • 2.8Mechanisms of Liver Function Regulation
  • 2.9Role of Antioxidants in Liver Health
  • 2.10Summary of Literature Review

Chapter THREE

RESEARCH METHODOLOGY

  • 3.1Research Methodology Overview
  • 3.2Selection of Experimental Animals
  • 3.3Preparation of Ethanolic Extract of Anchomanes difformis
  • 3.4Animal Grouping and Treatment Protocols
  • 3.5Measurement of Liver Function Parameters
  • 3.6Data Collection and Analysis Methods
  • 3.7Ethical Considerations in Animal Research
  • 3.8Statistical Analysis Procedures

Chapter FOUR

DATA PRESENTATION AND ANALYSIS

  • 4.1Overview of Research Findings
  • 4.2Effects of Anchomanes difformis Extract on Liver Enzymes
  • 4.3Impact on Liver Histology
  • 4.4Comparison with Control Group Results
  • 4.5Discussion on Antioxidant Properties
  • 4.6Potential Mechanisms of Action on Liver Functions
  • 4.7Interpretation of Results
  • 4.8Implications for Liver Health

Chapter FIVE

SUMMARY, CONCLUSION AND RECOMMENDATIONS

  • 5.1Conclusion and Summary
  • 5.2Summary of Research Objectives
  • 5.3Key Findings Recap
  • 5.4Contributions to Existing Knowledge
  • 5.5Practical Implications and Recommendations
  • 5.6Suggestions for Future Research

Project Abstract

<p> </p><div><p>This research was carried out to determine the effect of administration of <em>Achomanes Difformis (blume) </em>on liver functions in adult wistar rat, in which 20 adult wistar rats were purchased at the institute of advanced medical research and training (IMRAT), UCH, Ibadan. The rats were grouped into 4 in which there is a control group in which the rats were placed on normal diet and water. Other groups (A, B and C) were administered 300mg/kg/b.wt, 500mg/kg/b.wt and 700mg/kg/b.wt respectively. The herb was administered for duration of 14 days. Their cages were cleaned every day maintain proper hygiene. The rats were sacrificed immediately after two weeks of drug administration. From the result obtained, the administration of <em>Anchomanes difformis</em>&nbsp;has a hepatotoxic effect. It showed that there was an insignificant increase (p&gt;0.05) in the level of AST, ALT and ALP, and an insignificant decrease (p&gt;0.05) in the level of Total and Direct Bilirubin in the plasma at different dosage rate of the herb, when compared to the control group. The result demonstrates that the ingestion of <em>Anchomanes</em>&nbsp;<em>difformis </em>has a hepatotoxic effect in adult wistar rat.</p><p></p></div><h3></h3><br> <br><p></p>

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