Psychosocial functioning in parents of mps iii patients
Table Of Contents
Chapter ONE
INTRODUCTION
- 1.1Introduction
- 1.2Background of Study
- 1.3Problem Statement
- 1.4Objective of Study
- 1.5Limitation of Study
- 1.6Scope of Study
- 1.7Significance of Study
- 1.8Structure of the Research
- 1.9Definition of Terms
Chapter TWO
LITERATURE REVIEW
- 2.1Overview of Literature Review
- 2.2Theoretical Framework
- 2.3Historical Perspective
- 2.4Empirical Studies
- 2.5Conceptual Framework
- 2.6Key Concepts and Definitions
- 2.7Current Research Trends
- 2.8Critical Analysis of Existing Literature
- 2.9Research Gaps
- 2.10Summary of Literature Review
Chapter THREE
RESEARCH METHODOLOGY
- 3.1Research Methodology Overview
- 3.2Research Design
- 3.3Sampling Techniques
- 3.4Data Collection Methods
- 3.5Data Analysis Procedures
- 3.6Research Ethics
- 3.7Reliability and Validity
- 3.8Limitations of Methodology
Chapter FOUR
DATA PRESENTATION AND ANALYSIS
- 4.1Overview of Findings
- 4.2Demographic Analysis
- 4.3Quantitative Results
- 4.4Qualitative Analysis
- 4.5Comparative Analysis
- 4.6Interpretation of Findings
- 4.7Discussion of Results
- 4.8Implications of Findings
Chapter FIVE
SUMMARY, CONCLUSION AND RECOMMENDATIONS
- 5.1Conclusion and Summary
- 5.2Summary of Findings
- 5.3Contributions to Knowledge
- 5.4Recommendations for Future Research
- 5.5Practical Implications
Project Abstract
<p> </p><p><em>Background</em> Mucopolysaccharidosis type III (MPS III or Sanfilippo syndrome) is a lysosomal storage disease resulting in progressive neurocognitive decline during childhood and early demise. Its diagnosis may have a great impact on parents, potentially leading to psychosocial problems such as anxiety, depression, parental distress, and posttraumatic stress.</p><p><em>Methods</em> Twenty-six mothers and 19 fathers of 34 Dutch MPS III patients completed the “Hospital Anxiety and Depression Scale” (HADS), the “Distress Thermometer for Parents” (DT-P), and the “Self-Rating Scale for Posttraumatic Stress Disorders” (SRS-PTSD). Independent-sample T-tests and chi-square tests were used to assess differences between parents of MPS III patients and reference groups regarding anxiety and depression (HADS), distress (DT-P), and posttraumatic stress (SRS-PTSD).</p><p><em>Results</em> Mothers met the criteria for clinically relevant anxiety (50%) and depression (34.6%) more frequently compared to reference mothers (<em>p</em> = 0.001). Fathers more often met the criteria for clinically relevant depression (36.8%) compared to reference fathers (<em>p</em> = 0.022). Clinically relevant distress was highly prevalent in mothers (84.6%) and fathers (68.4%) of MPS III patients compared to reference parents (<em>p</em> < 0.01). Finally, the prevalence of PTSD was strikingly higher in both mothers (26.9%) and fathers (15%) than reported in the general Dutch population (respectively, <em>p</em> < 0.001 and <em>p</em> < 0.05).</p><p><em>Conclusions</em> We report a clinically relevant impact of parenting an MPS III patient on psychosocial functioning, which is demonstrated by high levels of anxiety, depression, distress, and a remarkably high prevalence of PTSD. Structural monitoring of the psychosocial functioning of MPS III parents is therefore essential and may be beneficial for the whole family.</p> <br><p></p>Project Overview
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