PHYTOCHEMICAL ANALYSIS AND THE ANTI-INFLAMMATORY ACTIVITIES OF DICHLOROMETHANE FRACTION OF METHHANOL EXTRACT OF CRATEVA ADANSONII

 

Table Of Contents


Chapter ONE

INTRODUCTION

  • 1.1Introduction
  • 1.2Background of Study
  • 1.3Problem Statement
  • 1.4Objective of Study
  • 1.5Limitation of Study
  • 1.6Scope of Study
  • 1.7Significance of Study
  • 1.8Structure of the Research
  • 1.9Definition of Terms

Chapter TWO

LITERATURE REVIEW

  • 2.1Overview of Phytochemicals
  • 2.2Importance of Phytochemical Analysis
  • 2.3Phytochemical Constituents in Plants
  • 2.4Methods for Phytochemical Analysis
  • 2.5Anti-Inflammatory Properties of Phytochemicals
  • 2.6Phytochemical Analysis Techniques
  • 2.7Role of Dichloromethane Fraction in Phytochemical Studies
  • 2.8Previous Studies on Crateva adansonii
  • 2.9Anti-Inflammatory Activities of Phytochemicals
  • 2.10Summary of Literature Review

Chapter THREE

RESEARCH METHODOLOGY

  • 3.1Research Methodology Overview
  • 3.2Selection of Research Design
  • 3.3Sampling Techniques
  • 3.4Data Collection Methods
  • 3.5Phytochemical Extraction Process
  • 3.6Anti-Inflammatory Assay Methods
  • 3.7Data Analysis Techniques
  • 3.8Ethical Considerations in Research

Chapter FOUR

DATA PRESENTATION AND ANALYSIS

  • 4.1Data Analysis and Interpretation
  • 4.2Phytochemical Profiles of Crateva adansonii Extract
  • 4.3Anti-Inflammatory Potential of Dichloromethane Fraction
  • 4.4Comparison with Previous Studies
  • 4.5Factors Influencing Anti-Inflammatory Activities
  • 4.6Discussion on Methodological Approaches
  • 4.7Implications of Findings
  • 4.8Future Research Directions

Chapter FIVE

SUMMARY, CONCLUSION AND RECOMMENDATIONS

  • 5.1Conclusion and Summary
  • 5.2Recap of Research Objectives
  • 5.3Key Findings Recap
  • 5.4Contribution to Existing Knowledge
  • 5.5Practical Implications
  • 5.6Recommendations for Further Research

Project Abstract

<p> </p><p>Inflammation is a complex biological response of vascular tissue to harmful stimuli such as pathogen, damage cells or irritants (Ryan &amp; Majno, 1983). The urgency generated by increased rate of stroke, atherosclerosis attribute due to prolonged use of cyclooxygenase-1 and Cyclooxygenase- 2 inhibitors have accelerated anti-inflammatory drug research over the last decade while synthetic pharmaceutical agents continued to dominate research (Ryan &amp; Majno, 1983). Attention increasingly has been directed to natural products. These are often more affordable and available and sometimes are perceived as more effective than conventional anti- inflammatory drugs.Anti-inflammation was carried out using 12 rats which was divided into three groups of 4 rats each. Group 1 and 2 served as the negative and positive control respectively. Group 3 received 25mg/kg b.w. of the dichloromethane fraction of methanol extract of Crateva adansonii showed significance anti-inflammatory activity when compared with the standard difference used.</p><br> <br><p></p>

Project Overview

<p> </p><p>Inflammation is one of body’s natural ways of protecting itself. It is also an essential reaction of the body to infection. Too little of an inflammatory response, and the body is unable to repel microbial invasions or heal injuries. Too much of an inflammatory response, and the immune system begins attacking the body’s own organs eventually leading to chronic disease (Sears, 2000). Anti-Inflammatory refers to the property of a substance or treatment that reduces inflammation. There are obvious clinical markers of inflammation which include pain, redness, fever, swelling and loss of function (Pai et al. 2004). However if inflammation is allowed to continue unchecked it may results in neurodegenerative disease or cancer (Pai et al. 2004). A variety of safe and effective anti-inflammatory agents are available including non-steroidal anti-inflammatory drugs, corticosteroids.</p><p></p><br> <br><p></p>

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