CARDIOPROTECTIVE ACTIVITIES OF N-HEXANE EXTRACT OF DESMODIUM VELUTINUM STEM ON ALBINO WISTAR RAT

Project Abstract

<p> <br>&nbsp; This study evaluates the cardioprotactive effect of <strong>N-hexane extract of Desmodium Velutinum stem on albino wistar rat. </strong>Rats used in this study were grouped into four and each group was fed differently. Rats in group one, three, and four were fed with the aid of a syringe without needle with 6ml of the lipoprotein food mixture containing 3.6g of the cow’s brain twice a day for seven days. Rats on group two was fed with only grower’s mash and water for seven days; rats in group three was later administered orally 2ml of dissolved vasoprin drug once in a day for 3 days.</p><p></p><p><strong>Rats</strong>&nbsp;in group four were also administered orally 0.5ml of the liquid drug extract of Desmodium Velutinum stem once a day for 3 days. During these three (3) days, the rats were given grower’s mash and water. After the feeding period, the rate fed with the cow’s brain showed a significant increases in the activities of marker enzymes such as creatine kinase (CK), creatine kinase MB (CKMB), Aspartate Transaminase (AST), Alanine Transaminase (ALT), and lactate dehydrogenase. This study shows that N-hexane extract of Desmodium Velutinum stem possess cardio protective effect on albino wistar rats than the known drug (vasoprin) if only one can increase the dosage of the extract for a period of time.</p> <br><p></p>

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