Home / Biochemistry / The effect of the ethanolic extract of anchomanes difformis (blume) on liver functions of adult wistar rats.

The effect of the ethanolic extract of anchomanes difformis (blume) on liver functions of adult wistar rats.

 

Table Of Contents


Chapter ONE

1.1 Introduction
1.2 Background of the Study
1.3 Problem Statement
1.4 Objective of the Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Research
1.9 Definition of Terms

Chapter TWO

2.1 Overview of Liver Functions
2.2 Review of Previous Studies on Liver Health
2.3 Effects of Plant Extracts on Liver Functions
2.4 Anchomanes difformis (Blume) Plant Description
2.5 Chemical Composition of Anchomanes difformis Extract
2.6 Pharmacological Properties of Anchomanes difformis Extract
2.7 Liver Diseases and Their Impact
2.8 Mechanisms of Liver Function Regulation
2.9 Role of Antioxidants in Liver Health
2.10 Summary of Literature Review

Chapter THREE

3.1 Research Methodology Overview
3.2 Selection of Experimental Animals
3.3 Preparation of Ethanolic Extract of Anchomanes difformis
3.4 Animal Grouping and Treatment Protocols
3.5 Measurement of Liver Function Parameters
3.6 Data Collection and Analysis Methods
3.7 Ethical Considerations in Animal Research
3.8 Statistical Analysis Procedures

Chapter FOUR

4.1 Overview of Research Findings
4.2 Effects of Anchomanes difformis Extract on Liver Enzymes
4.3 Impact on Liver Histology
4.4 Comparison with Control Group Results
4.5 Discussion on Antioxidant Properties
4.6 Potential Mechanisms of Action on Liver Functions
4.7 Interpretation of Results
4.8 Implications for Liver Health

Chapter FIVE

5.1 Conclusion and Summary
5.2 Summary of Research Objectives
5.3 Key Findings Recap
5.4 Contributions to Existing Knowledge
5.5 Practical Implications and Recommendations
5.6 Suggestions for Future Research

Project Abstract

This research was carried out to determine the effect of administration of Achomanes Difformis (blume) on liver functions in adult wistar rat, in which 20 adult wistar rats were purchased at the institute of advanced medical research and training (IMRAT), UCH, Ibadan. The rats were grouped into 4 in which there is a control group in which the rats were placed on normal diet and water. Other groups (A, B and C) were administered 300mg/kg/b.wt, 500mg/kg/b.wt and 700mg/kg/b.wt respectively. The herb was administered for duration of 14 days. Their cages were cleaned every day maintain proper hygiene. The rats were sacrificed immediately after two weeks of drug administration. From the result obtained, the administration of Anchomanes difformis has a hepatotoxic effect. It showed that there was an insignificant increase (p>0.05) in the level of AST, ALT and ALP, and an insignificant decrease (p>0.05) in the level of Total and Direct Bilirubin in the plasma at different dosage rate of the herb, when compared to the control group. The result demonstrates that the ingestion of Anchomanes difformis has a hepatotoxic effect in adult wistar rat.



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