Project Abstract

The project aims to explore the vast biodiversity of marine algae as a source of bioactive compounds with potential therapeutic applications. Marine ecosystems harbor a rich array of algal species, many of which remain largely unexplored for their medicinal and pharmaceutical potential. This project seeks to address the growing demand for novel, sustainable, and eco-friendly sources of natural products that can be utilized in the development of innovative drugs, nutraceuticals, and cosmeceuticals. The importance of this project lies in the untapped potential of marine algae as a source of bioactive molecules. Numerous studies have demonstrated the presence of a wide range of secondary metabolites in various algal species, including antioxidants, anti-inflammatory compounds, antimicrobial agents, and compounds with anticancer properties. However, the full spectrum of bioactive compounds present in marine algae and their underlying mechanisms of action are not yet fully understood. This project aims to address this knowledge gap and contribute to the advancement of marine-based drug discovery. The primary objectives of the project are to 1. Collect and screen a diverse array of marine algal samples from various coastal regions to identify species with high potential for bioactive compound production. 2. Develop efficient extraction and purification protocols to isolate and characterize the bioactive compounds present in the selected algal species. 3. Evaluate the biological activities of the isolated compounds, including their antimicrobial, antioxidant, anti-inflammatory, and anticancer properties. 4. Elucidate the chemical structures of the bioactive compounds using advanced analytical techniques, such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. 5. Investigate the mechanisms of action of the identified bioactive compounds and their potential applications in the development of pharmaceuticals, nutraceuticals, and cosmeceuticals. The project will utilize a multidisciplinary approach, combining expertise from the fields of marine biology, phycology, natural product chemistry, and pharmacology. The research team will collect and identify a diverse array of marine algal samples from various coastal regions, focusing on both micro- and macroalgae. Advanced extraction and purification techniques, such as solid-phase extraction, column chromatography, and high-performance liquid chromatography (HPLC), will be employed to isolate the bioactive compounds. The isolated compounds will be subjected to a comprehensive characterization process, including structural elucidation using NMR spectroscopy and mass spectrometry. Biological activity assays will be performed to evaluate the antimicrobial, antioxidant, anti-inflammatory, and anticancer properties of the compounds. Mechanism of action studies will be conducted to understand the underlying biochemical pathways and cellular targets of the bioactive compounds. The findings of this project will contribute to the growing body of knowledge on the medicinal and pharmaceutical potential of marine algae. The identification and characterization of novel bioactive compounds from marine algae may lead to the development of innovative drug candidates, nutraceuticals, and cosmeceuticals. Furthermore, the project may provide insights into sustainable and eco-friendly approaches to natural product-based drug discovery and development.

Project Overview