<p>1. Introduction<br> 1.1 Background<br> 1.2 Significance of the Study<br>2. Literature Review<br> 2.1 Lung Cancer: Overview and DNA Damage<br> 2.2 DNA Damage and Repair Mechanisms<br> 2.3 DNA Repair Deficiencies in Cancer<br>3. Research Objectives<br>4. Methodology<br> 4.1 Cell Culture and DNA Damage Induction<br> 4.2 DNA Repair Assays<br> 4.3 Genomic Analysis of DNA Repair Genes<br> 4.4 Functional Analysis of DNA Repair Pathways<br>5. Results and Discussion<br> 5.1 Characterization of DNA Repair Capacity in Lung Cancer Cells<br> 5.2 Identification of DNA Repair Deficiencies in Lung Cancer<br> 5.3 Impact of DNA Repair Defects on Drug Response<br> 5.4 Therapeutic Strategies Targeting DNA Repair Deficiencies<br></p>
DNA damage and repair mechanisms play a critical role in maintaining genomic integrity and preventing the development of cancer. This project aims to study the mechanisms of DNA damage and repair in lung cancer, with a focus on understanding the molecular pathways involved in DNA repair defects. Through a combination of molecular biology techniques, genomic analysis, and functional assays, we will investigate the DNA repair capacity of lung cancer cells and identify key genes and pathways associated with DNA repair deficiencies. Additionally, we will explore the impact of DNA repair defects on the response to DNA-damaging agents and potential therapeutic strategies. The findings from this study will contribute to our understanding of the biochemistry of DNA damage and repair in lung cancer and may have implications for personalized treatment approaches.
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