Studying the mechanisms of DNA damage and repair in aging
Table Of Contents
<p>1. Introduction<br> 1.1 Background<br> 1.2 Significance of the study<br>2. Types of DNA damage in aging<br> 2.1 Oxidative DNA damage<br> 2.2 DNA strand breaks<br> 2.3 DNA base modifications<br>3. DNA repair pathways in aging<br> 3.1 Base excision repair<br> 3.2 Nucleotide excision repair<br> 3.3 Mismatch repair<br> 3.4 Double-strand break repair<br>4. Factors influencing DNA repair efficiency in aging<br> 4.1 DNA repair enzymes and proteins<br> 4.2 Epigenetic modifications<br> 4.3 Cellular senescence and DNA repair<br>5. Methods<br> 5.1 Cell culture and aging models<br> 5.2 DNA damage assessment techniques<br> 5.3 DNA repair assays<br><br></p>
Project Abstract
This project aims to study the mechanisms of DNA damage and repair in aging. DNA damage is a common occurrence in cells, and its accumulation over time is believed to contribute to the aging process and age-related diseases. Understanding the mechanisms of DNA damage and repair in aging is crucial for developing strategies to maintain genomic stability and promote healthy aging. This study will investigate the types of DNA damage that accumulate with age, the repair pathways involved, and the factors that influence DNA repair efficiency in aging cells. The findings will contribute to the knowledge of the molecular basis of aging and may have implications for interventions to promote healthy aging.
Project Overview
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