Investigating the role of biochemistry in drug safety assessment
Table Of Contents
<p>1. Introduction<br> 1.1 Background<br> 1.2 Objectives<br>2. Biochemical Mechanisms of Drug Toxicity<br> 2.1 Drug Metabolism and Activation<br> 2.2 Reactive Metabolite Formation<br> 2.3 Oxidative Stress and Cellular Damage<br>3. Techniques for Assessing Drug Safety<br> 3.1 In Vitro Toxicity Testing<br> 3.2 In Vivo Toxicity Testing<br> 3.3 High-Throughput Screening<br>4. Biomarkers in Drug Safety Assessment<br> 4.1 Biochemical Biomarkers<br> 4.2 Genetic Biomarkers<br> 4.3 Omics Technologies<br>5. Predictive Models for Drug-Induced Toxicity<br> 5.1 Quantitative Structure-Activity Relationship (QSAR) Models<br> 5.2 Physiologically-Based Pharmacokinetic (PBPK) Models<br> 5.3 Systems Biology Approaches<br></p>
Project Abstract
Drug safety assessment is a critical step in the drug development process. This project aims to investigate the role of biochemistry in drug safety assessment and its implications in predicting and preventing adverse drug reactions. The project will involve studying the various biochemical mechanisms underlying drug toxicity, including drug metabolism, reactive metabolite formation, and oxidative stress. Additionally, the project will explore the techniques used to assess drug safety, such as in vitro and in vivo toxicity testing, as well as the role of biomarkers in predicting drug-induced toxicity. By understanding the biochemistry of drug safety assessment, this project aims to contribute to the development of safer and more effective drugs.
Project Overview
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