Studying the mechanisms of DNA damage and repair in cancer
Table Of Contents
<p>1.Introduction 1.1 Background<br> 1.2 Objectives<br>2. DNA damage and genomic instability in cancer<br> 2.1 Types of DNA damage<br> 2.2 Sources of DNA damage in cancer<br> 2.3 Impact of DNA damage on genomic integrity<br>3. DNA repair pathways in cancer<br> 3.1 Base excision repair (BER)<br> 3.2 Nucleotide excision repair (NER)<br> 3.3 Mismatch repair (MMR)<br> 3.4 Homologous recombination (HR)<br> 3.5 Non-homologous end joining (NHEJ)<br>4. Interplay between DNA repair and cancer progression<br> 4.1 DNA repair gene mutations in cancer<br> 4.2 DNA repair and resistance to therapy<br> 4.3 DNA repair as a therapeutic target<br>5. Emerging strategies for targeting DNA repair in cancer<br> 5.1 PARP inhibitors<br> 5.2 DNA repair gene targeting<br> 5.3 Combination therapies involving DNA repair inhibitors<br></p>
Project Abstract
DNA damage is a common occurrence in cells, and if left unrepaired, it can lead to genomic instability and the development of cancer. Understanding the mechanisms of DNA damage and repair in cancer is crucial for the development of targeted therapies and personalized medicine approaches. This project aims to study the mechanisms of DNA damage and repair in cancer by investigating the role of DNA repair pathways, the impact of DNA damage on genomic integrity, and the interplay between DNA repair and cancer progression. Additionally, the project will explore the potential of targeting DNA repair pathways as a therapeutic strategy for cancer treatment. The findings from this study will contribute to a better understanding of the biochemistry underlying DNA damage and repair in cancer and may have implications for the development of novel cancer therapies.
Project Overview
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