Home / Biochemistry / CARDIOPROTECTIVE ACTIVITIES OF N-HEXANE EXTRACT OF DESMODIUM VELUTINUM STEM ON ALBINO WISTAR RAT

CARDIOPROTECTIVE ACTIVITIES OF N-HEXANE EXTRACT OF DESMODIUM VELUTINUM STEM ON ALBINO WISTAR RAT

 

Table Of Contents


Chapter ONE

1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Research
1.9 Definition of Terms

Chapter TWO

2.1 Overview of Cardioprotective Activities
2.2 N-Hexane Extract
2.3 Desmodium Velutinum Stem
2.4 Biological Activities of Desmodium Velutinum
2.5 Mechanisms of Cardioprotection
2.6 Previous Research on Cardioprotection
2.7 Animal Models for Cardioprotection Studies
2.8 Molecular Targets for Cardioprotection
2.9 Phytochemical Composition of N-Hexane Extract
2.10 Pharmacological Actions of N-Hexane Extract

Chapter THREE

3.1 Research Methodology Overview
3.2 Selection of Research Design
3.3 Sampling Techniques
3.4 Data Collection Methods
3.5 Data Analysis Procedures
3.6 Ethical Considerations
3.7 Validity and Reliability of Data
3.8 Statistical Tools Used

Chapter FOUR

4.1 Cardioprotective Effects of N-Hexane Extract
4.2 Evaluation of Desmodium Velutinum Stem Extract
4.3 Comparison with Other Plant Extracts
4.4 Dosage and Administration of Extract
4.5 Side Effects and Safety Profile
4.6 Discussion on Mechanisms of Action
4.7 Clinical Implications of Findings
4.8 Future Research Directions

Chapter FIVE

5.1 Summary of Findings
5.2 Conclusions Drawn
5.3 Recommendations for Future Studies
5.4 Practical Implications of Research
5.5 Contribution to Scientific Knowledge

Thesis Abstract


  This study evaluates the cardioprotactive effect of N-hexane extract of Desmodium Velutinum stem on albino wistar rat. Rats used in this study were grouped into four and each group was fed differently. Rats in group one, three, and four were fed with the aid of a syringe without needle with 6ml of the lipoprotein food mixture containing 3.6g of the cow’s brain twice a day for seven days. Rats on group two was fed with only grower’s mash and water for seven days; rats in group three was later administered orally 2ml of dissolved vasoprin drug once in a day for 3 days.

Rats in group four were also administered orally 0.5ml of the liquid drug extract of Desmodium Velutinum stem once a day for 3 days. During these three (3) days, the rats were given grower’s mash and water. After the feeding period, the rate fed with the cow’s brain showed a significant increases in the activities of marker enzymes such as creatine kinase (CK), creatine kinase MB (CKMB), Aspartate Transaminase (AST), Alanine Transaminase (ALT), and lactate dehydrogenase. This study shows that N-hexane extract of Desmodium Velutinum stem possess cardio protective effect on albino wistar rats than the known drug (vasoprin) if only one can increase the dosage of the extract for a period of time.


Thesis Overview

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