Thesis Abstract

Abstract
MicroRNAs (miRNAs) are small non-coding RNA molecules that play crucial roles in gene regulation and have been implicated in various biological processes, including cancer progression. This thesis explores the role of miRNAs in cancer development and their potential as therapeutic targets in cancer treatment. The study focuses on understanding the mechanisms by which miRNAs contribute to cancer progression and how they can be targeted for therapeutic interventions. The introduction provides a comprehensive overview of miRNAs, cancer biology, and the rationale for studying miRNAs in cancer. The background of the study delves into the current understanding of miRNAs and their dysregulation in cancer, highlighting their significance in cancer development and progression. The problem statement identifies the gaps in knowledge regarding specific miRNAs and their roles in different types of cancer. The objectives of the study outline the research goals and aims to address these knowledge gaps. The limitations of the study acknowledge the challenges and constraints that may affect the research outcomes. The scope of the study defines the boundaries and focus areas of the research. The significance of the study highlights the potential impact of this research on cancer treatment and patient outcomes. The structure of the thesis provides a roadmap for the organization of the research work, guiding readers through the chapters and sections. The literature review critically examines existing research on miRNAs in cancer, discussing their roles in tumor initiation, progression, metastasis, and drug resistance. The research methodology describes the experimental approaches and techniques used to investigate miRNAs in cancer, including cell culture studies, animal models, and bioinformatics analysis. The discussion of findings presents the research results, highlighting the key miRNAs involved in cancer progression and their potential as therapeutic targets. The implications of these findings for cancer treatment and future research directions are discussed in detail. In conclusion, this thesis provides insights into the role of miRNAs in cancer progression and their potential as therapeutic targets. The findings contribute to our understanding of the molecular mechanisms underlying cancer development and offer new perspectives on personalized cancer therapy. Overall, this research sheds light on the importance of miRNAs in cancer biology and opens up new avenues for targeted cancer treatment strategies.

Thesis Overview

The project titled "Exploring the role of microRNAs in cancer progression and potential therapeutic applications" aims to investigate the intricate involvement of microRNAs in the progression of cancer and their potential as targets for therapeutic interventions. This research seeks to delve into the molecular mechanisms through which microRNAs contribute to tumor development and metastasis, with a focus on identifying specific microRNAs that play crucial roles in different types of cancer. The study will involve a comprehensive literature review to gather existing knowledge on the functions and dysregulation of microRNAs in cancer. By synthesizing information from various sources, the research aims to identify key microRNAs that are commonly dysregulated in cancer and elucidate their specific roles in promoting tumor growth, invasion, and resistance to treatment. Furthermore, the project will include experimental investigations to validate the functional significance of selected microRNAs in cancer progression. Using cell culture models and potentially animal studies, the research will aim to demonstrate the effects of modulating specific microRNAs on cancer cell behavior, such as proliferation, migration, and response to therapy. In addition to elucidating the biological roles of microRNAs in cancer, this project will also explore the therapeutic potential of targeting dysregulated microRNAs for the treatment of cancer. By investigating the feasibility and efficacy of using microRNA-based therapies, such as antagomirs or mimics, the research aims to provide insights into novel strategies for combating cancer by modulating microRNA expression. Overall, this research overview highlights the significance of understanding the role of microRNAs in cancer progression and the potential implications for developing innovative therapeutic approaches. By unraveling the complex interplay between microRNAs and cancer pathogenesis, this project seeks to contribute valuable insights to the field of oncology and pave the way for the development of targeted and personalized treatments for cancer patients.