Home / Biochemistry / The anti-inflammatory activityof crateva adansonii dichloromethane fraction.

The anti-inflammatory activityof crateva adansonii dichloromethane fraction.

 

Table Of Contents


Chapter ONE

1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Research
1.9 Definition of Terms

Chapter TWO

2.1 Overview of Anti-Inflammatory Activity
2.2 Crateva Adansonii: Botanical Information
2.3 Traditional Uses of Crateva Adansonii
2.4 Phytochemical Composition of Crateva Adansonii
2.5 Previous Studies on Crateva Adansonii
2.6 Mechanisms of Anti-Inflammatory Activity
2.7 Other Natural Anti-Inflammatory Agents
2.8 Clinical Applications of Anti-Inflammatory Agents
2.9 Challenges in Anti-Inflammatory Research
2.10 Future Directions in Anti-Inflammatory Research

Chapter THREE

3.1 Research Design
3.2 Selection of Research Methods
3.3 Data Collection Procedures
3.4 Sampling Techniques
3.5 Data Analysis Methods
3.6 Ethical Considerations
3.7 Reliability and Validity
3.8 Limitations of the Research

Chapter FOUR

4.1 Analysis of Data Collected
4.2 Presentation of Findings
4.3 Comparison with Existing Literature
4.4 Interpretation of Results
4.5 Discussion of Key Findings
4.6 Implications of the Findings
4.7 Recommendations for Future Research
4.8 Practical Applications of the Findings

Chapter FIVE

5.1 Summary of Findings
5.2 Conclusions Drawn from the Study
5.3 Contributions to the Field
5.4 Reflection on Research Process
5.5 Recommendations for Further Action

Thesis Abstract

The abstract of the research is as follows The anti-inflammatory activity of Crateva adansonii dichloromethane fraction was investigated in this study. Crateva adansonii is a medicinal plant traditionally used in Nigerian folk medicine for its anti-inflammatory properties. The dichloromethane fraction of Crateva adansonii was prepared using standard extraction methods. The anti-inflammatory activity was evaluated using in vitro and in vivo models. In the in vitro model, the dichloromethane fraction showed significant inhibition of inflammatory mediators such as nitric oxide, prostaglandins, and cytokines in lipopolysaccharide-stimulated RAW 264.7 macrophages. The fraction also exhibited antioxidant activity by reducing reactive oxygen species levels in the cells. These results suggest that the dichloromethane fraction of Crateva adansonii possesses potent anti-inflammatory and antioxidant properties. In the in vivo model, the anti-inflammatory activity of the dichloromethane fraction was evaluated using carrageenan-induced paw edema in rats. The fraction significantly reduced paw edema at different time points compared to the control group. Additionally, the fraction showed a dose-dependent effect on paw swelling, further supporting its anti-inflammatory activity in vivo. Further analysis of the dichloromethane fraction revealed the presence of bioactive compounds such as flavonoids, alkaloids, and tannins, which are known for their anti-inflammatory and antioxidant properties. The phytochemical analysis confirmed the potential of Crateva adansonii dichloromethane fraction as a source of bioactive compounds with medicinal properties. Overall, this study demonstrates the anti-inflammatory activity of Crateva adansonii dichloromethane fraction both in vitro and in vivo. The fraction showed inhibition of inflammatory mediators and reduction of paw edema in rats, indicating its potential as a natural anti-inflammatory agent. The presence of bioactive compounds in the fraction further supports its traditional use in Nigerian folk medicine for treating inflammatory conditions. Further research is warranted to elucidate the mechanisms of action and to explore the therapeutic potential of Crateva adansonii dichloromethane fraction in the treatment of inflammatory diseases.

Thesis Overview

1.0     Introduction

Previously, voting for general and local elections is done by electors with voting papers and voting boxes in which the voting papers are placed. This method reveals some kinds of negative situations. Not been able to determine which party the stamp belongs to, the probability of placing the voting papers in wrong box, problems with counting the votes, loss of time when there happens to be some objections, paper printing and expenditures done for personel are some of the disadvatages of classical election system. The secret ballot is a fundamental instrument for protecting the freedom of choice of voters. For this reason, it is necessary to use new technologies for making the election system more trustable, economic and faster.

Electronic election system is set into use in some countries, especially in USA and Europe, at the beginning of nineties as a result of innovating technology and it became more trustable by improving itself at the present day. Electronic voting is an activity of realising the voting in electronic environment. Electronic election is a system which enables fast counting by electronic voting.

Electronic voting is used in some countries in the world and there are also studies about it (Babu and Padmavathamma, 2006; El-qawasmeh and Owais, 2010;

Folorunso et al., 2005; Hajjar et al., 2006). Electronic voting is used for parliamentary elections in Australia in 2001 (Schoen and Faas, 2005), for student union elections in Austria in 2003 (Prosser et al., 2003), for municipal elections in Canada in 2003 (Nakhaie, 2006), for both general and local elections in India in 2003 (Gorla, 2009). As a result of developments on information technologies in recent years, public opinion polls and nation-wide general elections will be realized faster and more effectively on electronic environment.

Nowadays, security problems are experienced with the fast developing technology. Besides developing the system, there are also so many studies and new methods for solving the security problems of the developing system. As a result of developing technology, individual password is started to be used to meet the security requirements. In time, new methods are developed and card technologies are used due to closing the security holes about burglary of the cards or forgetting the individual passwords. Usage of the ID cards and Private Identification Numbers (PIN) become widespread at card technologies (Sonkamble et al., 2010; Alkan and Bulut, 2010). Researches on security and identification operations according to physical characteristics are realized due to limitations of this technology in time.

Biometric systems are the methods which make identification of people according to their physical characteristics. Biometric methods consist of fingerprint, face, hand shape, retina, iris, and voice track methods (Sonkamble et al., 2010; Kadry and Smaili, 2010; Razzak et al., 2010). These methods may be used alone or together in the developed systems.

Fingerprint recognition method and ID system in biometric methods are frequently preferred because applications of them are easy and low-cost (Maltoni et al., 2009). Fingerprint recognition system is the leading method because everyone has different fingerprints, can not be changed easily and probability of loosing, forgeting and stealing of it is impossible. Besides, every finger has distinctive characteristics because fingerprints of every finger of a person are different (Altun et al., 2008).

For this reason, fingerprint method is used mostly alone or together with other biometric methods for providing security of the systems. Fingerprint method is also used for identification of the internet applications.

In this study, biometric authentication system is aimed instead of traditional election systems. By developing the deficiencies of the present system, biometric based election system has been developed.

 

1.1     Background of the Study

Voting theory formally began in the 18th century and ever since, many proposal has been made towards using electronic technologies to improve elections (Sobia, Ummer, Ayesha, Usman, and Hassan, 2011). One of the essential features of democracy is Election, democracy encourages individual’s freedom with respect to the rule of law, so that individuals can express their opinion the way they wish, giving individuals the opportunity to decide their leaders, and uninhibitedly express their feelings on issues. Because of the All-inclusive Affirmation of Human Rights in the year 1948 that puts import on compelling circumstance of free elections, countries focused on an improved and new voting process that are of significance to the election processes in the 21st century (Salomonsen, 2005).

Election is the process that enables individuals to choose their delegates and express their fellings on the way they will be administered (Kohno, Rubin, Stubblefield & Wallach, 2003), (Malkawi, Khasawneh & Al-Jarrah, 2009) and (Ashok & Ummal, 2011).

Nigerian election process has been done manually (voting for local and general elections done by electors with ballot papers and ballot boxes in which the papers are placed) since returned to democratic rule in the year 1999, the manual voting process was associated with a lot of problems and always resulted to post-election violence (Yekini, Oyeyinka, Oludipe & Lawal, 2012).

In the Federal republic of Nigeria, voting system is of two main categories, Manual Voting System (MVS) and Electronic Voting System (EVS).

The Manual Voting System (MVS) involves presenting eligible citizen with a list of contestants on a paper called ballot paper, to mark against their favorite contestants and place the ballot paper in a box called ballot box, this system of voting is used for senatorial and governorship election processes in the country. Manual voting system has some disadvantages, which include possibility of placing the ballot paper in the wrong ballot box, votes counting problem, loss of time when there happens to be some objections, paper printing and expenditures done for personnel, for these reasons, it is necessary to use the new technologies to make the election system faster, economic and trustable because the trust that every vote will be tallied and recorded correctly is the foundation of a genuine democracy (Ademand & Metin, 2011).

The Electronic Voting System (EVS) involves presenting eligible citizen with a list of contestants on a computer, to select against their favorite contestants, this system of voting is used for presidential election in the country. The improvement of information and communications technologies has allow for a completely computerised election process whereby counting of vote are carried out in real time, that the results are automatically out by the end of elections day (Rubin, 2002).

 

1.2     Statement of the Problem

With advances in information and communication technology, issue of security has gone far beyond ordinary password usage. This project sought to describe the biometric authentication system, as an improved solution to the existing voting system of the Federal Republic of Nigeria. The existing system is however subjected to possible loss of card, failure to card verification, and unguaranteed voter’s presence at the point and time of election. Furthermore, the EVS existing system is used for the presidential election, while manual voting system of ballot paper and ballot box is used for senatorial and governorship elections.

 

1.3       Aim and Objectives of the Study

This project aimed at the development of a windows application for the design and implementation of a biometrics authentication system for voters and voting process, with an embedded fingerprint, for user’s authentication to the system.

The following are the objectives of this study:

  1. To study the existing voting method use for election in the country for senatorial and governorship candidates in elections process.
  2. To design a robust and secured system of voting using fingerprint biometric authentication recognition process.
  3. To implement biometrics system form voters and voting process in the country for senatorial election.

 

1.4     Significance of the Study

The significance of this project are to improve confidentiality, integrity and voter’s identification in voting process, to reduce the time and stress of conducting manual election (senatorial and governorship), and to provide equal level of security at the election ground.

 

1.5     Scope of the Study

This project is purposely designed for the Independent National Electoral Commission (INEC) election in the Federal Republic of Nigeria to overcome the problem of illegal activities during election, by making sure only eligible voters have access to the system, immediately outputting the results of the election, and ensuring that voters have trust in the process of election. However, this system can be extended to other electoral system with little or no modifications.

 

1.6     Limitations of the Study

Despite all the significance of this project, it is also subjected to some limitations, which includes the fact that it’s a desktop application, it cannot be used by the citizens at their convenience but has to come to the pull for the election, and only a fingerprint reader from Digital persona Inc. can be used for the enrollment and verification of user to the system.

 

1.7     Definition of Term

EVS – On line electronic voting system

E-voting – Electronic Voting

INEC – Independent National Electoral Commission

EVR – Electronic Voter Register

PU     – Polling Unit

ICT- Information and communication Technology

ECIL- Federal Election Commission

ES & S –     Election systems & software

VVPAT- vote verifiable paper audit trails

PEB- Personal Electronic Ballot

PIN- Personal Identity Number

MBB- Mobile Ballot Box

JBC- judges Booth Controller


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