Thesis Abstract

Abstract
Cancer remains a significant health challenge worldwide, with the need for innovative therapeutic strategies becoming increasingly urgent. MicroRNAs (miRNAs) have gained attention in the field of cancer research due to their crucial roles in regulating gene expression and cellular processes. This thesis aims to explore the role of miRNAs in cancer progression and their therapeutic implications. The introduction provides a background to the study, highlighting the importance of understanding the molecular mechanisms underlying cancer development and progression. The problem statement emphasizes the need for novel therapeutic approaches to combat the complexities of cancer. The objectives of the study are outlined to investigate the specific roles of miRNAs in different types of cancer and evaluate their potential as therapeutic targets. The literature review delves into existing research on miRNAs in various types of cancer, focusing on their roles in tumor initiation, progression, and metastasis. The review highlights the diverse functions of miRNAs in cancer biology and their potential as diagnostic and prognostic markers. The research methodology section outlines the experimental approaches used to investigate the expression profiles and functional significance of specific miRNAs in cancer cells. Techniques such as qRT-PCR, microarray analysis, and functional assays are employed to elucidate the molecular mechanisms underlying the effects of miRNAs on cancer progression. The discussion of findings section presents the results of the experimental studies, highlighting the differential expression patterns of specific miRNAs in different cancer types and their impact on key signaling pathways involved in tumorigenesis. The implications of these findings for developing novel therapeutic strategies targeting miRNAs are discussed in detail. In conclusion, this thesis provides valuable insights into the role of miRNAs in cancer progression and their potential as therapeutic targets. The findings underscore the importance of further research to exploit the therapeutic implications of miRNAs in cancer treatment. Overall, this study contributes to advancing our understanding of the complex interplay between miRNAs and cancer biology, paving the way for the development of innovative and personalized cancer therapies.

Thesis Overview

The research project titled "Exploring the Role of MicroRNAs in Cancer Progression and Therapeutic Implications" aims to investigate the intricate involvement of microRNAs in cancer development and progression, as well as their potential therapeutic implications. MicroRNAs are short non-coding RNA molecules that regulate gene expression at the post-transcriptional level and play critical roles in various cellular processes, including cell proliferation, differentiation, and apoptosis. The project will begin with a comprehensive review of the current understanding of microRNAs in cancer biology, highlighting their aberrant expression patterns in different types of cancer and their functional roles in promoting or suppressing tumor growth. This literature review will provide a solid foundation for understanding the significance of targeting microRNAs as a novel approach in cancer therapy. The research methodology will involve experimental approaches to investigate specific microRNAs associated with cancer progression. This will include the identification of dysregulated microRNAs in cancer cell lines and patient samples, as well as functional studies to elucidate their effects on key signaling pathways involved in tumorigenesis. The use of advanced molecular biology techniques, such as RNA sequencing, qRT-PCR, and functional assays, will be employed to characterize the role of microRNAs in cancer progression. The findings from this study will be discussed in detail in Chapter Four, focusing on the implications of the identified microRNAs as potential therapeutic targets in cancer treatment. The results will be analyzed in the context of current cancer therapies and the challenges associated with targeting microRNAs in clinical settings. The discussion will also explore the potential of using microRNAs as diagnostic biomarkers for cancer detection and prognosis. In conclusion, this research project will contribute to the growing body of knowledge on the role of microRNAs in cancer progression and provide new insights into their therapeutic implications. By elucidating the molecular mechanisms underlying the involvement of microRNAs in cancer development, this study has the potential to identify novel therapeutic targets and strategies for improving cancer treatment outcomes.