Thesis Abstract

Abstract
Cancer is a complex disease characterized by uncontrolled cell growth and proliferation, leading to the formation of tumors. MicroRNAs (miRNAs) are small non-coding RNA molecules that play crucial roles in regulating gene expression and have been implicated in various cellular processes, including cancer development and progression. This thesis aims to explore the role of miRNAs in cancer, focusing on their involvement in the initiation, promotion, and metastasis of tumors. Chapter One provides an introduction to the topic, including background information on miRNAs, the problem statement, objectives of the study, limitations, scope, significance, and structure of the thesis. The definitions of key terms related to miRNAs and cancer are also provided to establish a foundational understanding for the subsequent chapters. Chapter Two presents a comprehensive literature review of current research on miRNAs in cancer, highlighting key findings and identifying gaps in knowledge. The review covers various aspects, including the dysregulation of miRNAs in different cancer types, their mechanisms of action, and their potential diagnostic and therapeutic implications. Chapter Three outlines the research methodology employed in this study. This chapter details the experimental techniques used to investigate the expression profiles of specific miRNAs in cancer cells and tissues, as well as the bioinformatics analyses employed to identify miRNA targets and pathways associated with cancer development and progression. Chapter Four presents the findings of the study, focusing on the role of specific miRNAs in promoting cancer cell proliferation, migration, and invasion. The results demonstrate the dysregulation of miRNAs in cancer cells and their impact on key signaling pathways involved in tumor growth and metastasis. Chapter Five summarizes the key findings of the study and provides a conclusion based on the results obtained. The implications of the research findings for cancer diagnosis, prognosis, and treatment are discussed, along with recommendations for future research directions in the field of miRNA-based cancer therapeutics. Overall, this thesis contributes to the growing body of knowledge on the role of miRNAs in cancer development and progression, shedding light on the intricate molecular mechanisms underlying tumorigenesis and offering insights into potential therapeutic strategies for combating this deadly disease.

Thesis Overview

The project titled "Exploring the Role of MicroRNAs in Cancer Development and Progression" aims to investigate the intricate involvement of microRNAs (miRNAs) in the development and progression of cancer. MicroRNAs are small non-coding RNA molecules that play crucial roles in post-transcriptional regulation of gene expression. They have been increasingly recognized for their significant impact on various cellular processes, including cell proliferation, differentiation, and apoptosis. Cancer is a complex disease characterized by uncontrolled cell growth and the ability to invade surrounding tissues. Understanding the role of miRNAs in cancer development is essential for identifying potential biomarkers for early detection, as well as therapeutic targets for cancer treatment. This research project seeks to unravel the specific miRNAs involved in different types of cancer and elucidate their mechanisms of action in promoting tumorigenesis and metastasis. The study will involve a comprehensive literature review to explore the current knowledge surrounding the role of miRNAs in cancer. By analyzing existing research findings, this project aims to identify key miRNAs that are dysregulated in various cancer types and understand how they contribute to tumor initiation and progression. Furthermore, the research methodology will include experiments to validate the functional significance of specific miRNAs in cancer cell lines and animal models. The findings from this investigation are expected to provide valuable insights into the molecular mechanisms underlying cancer development and progression. By elucidating the role of miRNAs in these processes, this project has the potential to uncover novel diagnostic and therapeutic strategies for combatting cancer. Ultimately, the research outcomes aim to contribute to the advancement of precision medicine approaches that target specific miRNAs for personalized cancer treatment. In summary, the project on "Exploring the Role of MicroRNAs in Cancer Development and Progression" represents a significant endeavor to deepen our understanding of the molecular mechanisms driving cancer pathogenesis. Through a comprehensive analysis of miRNA dysregulation in cancer, this research aims to pave the way for innovative strategies to diagnose, treat, and potentially prevent cancer progression.