Thesis Abstract

Abstract
MicroRNAs (miRNAs) are small non-coding RNA molecules that play crucial roles in cancer progression and have emerged as potential therapeutic targets for cancer treatment. This thesis aims to explore the intricate role of miRNAs in cancer progression and their therapeutic potential. The study involves a comprehensive review of existing literature on miRNAs in cancer, an analysis of their mechanisms of action, and an investigation into their potential as diagnostic and therapeutic tools in cancer management. Chapter One provides a detailed introduction to the research topic, outlining the background of the study, the problem statement, objectives, limitations, scope, significance, structure of the thesis, and definitions of key terms. Chapter Two consists of a thorough literature review encompassing ten key aspects related to miRNAs in cancer progression and therapy. The review covers the regulatory functions of miRNAs in cancer, their role in tumor initiation and progression, and their potential as biomarkers and therapeutic targets. Chapter Three delves into the research methodology, detailing the research design, data collection methods, sample selection criteria, experimental procedures, data analysis techniques, and ethical considerations. The chapter also discusses the challenges encountered during the research process and the strategies employed to address them. In Chapter Four, the findings of the study are presented and discussed in depth. The results highlight the specific miRNAs implicated in different cancer types, their mechanisms of action, and their potential as therapeutic targets. The chapter also explores the challenges and opportunities associated with harnessing miRNAs for cancer therapy. Finally, Chapter Five presents the conclusion and summary of the thesis, summarizing the key findings, discussing their implications for cancer research and therapy, and suggesting avenues for future research. The thesis concludes by emphasizing the potential of miRNAs as valuable tools for understanding cancer biology and developing novel therapeutic interventions. Overall, this thesis contributes to the growing body of knowledge on the role of miRNAs in cancer progression and therapy, shedding light on their potential as diagnostic markers and therapeutic targets. The findings have implications for the development of innovative cancer treatment strategies that leverage the regulatory functions of miRNAs to combat cancer progression effectively.

Thesis Overview

The project titled "Exploring the Role of MicroRNAs in Cancer Progression and Therapeutic Potential" aims to investigate the intricate roles of microRNAs in cancer progression and explore their potential as therapeutic targets. Cancer is a complex disease characterized by uncontrolled cell growth and proliferation, often leading to metastasis and resistance to treatment. MicroRNAs, small non-coding RNA molecules, have emerged as key regulators of gene expression and are implicated in various cellular processes, including cell proliferation, apoptosis, and differentiation. The research will begin with a comprehensive literature review to provide a deep understanding of the current knowledge surrounding microRNAs and their involvement in cancer development and progression. This will include an examination of the different microRNAs identified in various types of cancer, their targets, and the mechanisms through which they exert their effects. The methodology chapter will outline the experimental approaches to be employed in the study, including the collection and analysis of biological samples, such as tumor tissues and blood samples, to investigate the expression levels of specific microRNAs in cancer patients. Various molecular biology techniques, such as quantitative real-time polymerase chain reaction (qRT-PCR) and bioinformatics analysis, will be utilized to study the functional roles of microRNAs in cancer cells. The discussion of findings chapter will present the results obtained from the experimental analyses, highlighting any correlations between microRNA expression levels and clinical parameters, such as tumor stage, grade, and patient survival. The implications of these findings for cancer diagnosis, prognosis, and treatment will be critically evaluated, with a focus on the potential of targeting specific microRNAs for therapeutic intervention. In conclusion, this research project will provide valuable insights into the roles of microRNAs in cancer progression and their potential as novel therapeutic targets. By elucidating the molecular mechanisms underlying the dysregulation of microRNAs in cancer, this study aims to contribute to the development of more effective diagnostic and therapeutic strategies for cancer patients.