Thesis Abstract

**Abstract
** MicroRNAs (miRNAs) are small non-coding RNA molecules that play crucial roles in regulating gene expression and have been implicated in various cellular processes, including cancer development and progression. This thesis aims to explore the role of miRNAs in cancer development and progression, focusing on their mechanisms of action, diagnostic potential, and therapeutic implications. The introduction provides a background of miRNAs and their significance in cancer biology. The problem statement highlights the gaps in current knowledge regarding specific miRNAs involved in different types of cancer and their potential as biomarkers or therapeutic targets. The objectives of the study include identifying key miRNAs associated with cancer, investigating their functions, and evaluating their clinical relevance. The literature review chapter synthesizes existing research on miRNAs in cancer, covering topics such as the dysregulation of miRNAs in various cancer types, their roles in tumor initiation and progression, and their potential as diagnostic or prognostic markers. The chapter also discusses the challenges and opportunities in targeting miRNAs for cancer therapy. The research methodology chapter outlines the experimental approaches used to investigate miRNAs in cancer, including bioinformatics analysis, cell culture studies, and animal models. It details the selection criteria for miRNA targets, sample collection methods, and data analysis techniques. The findings chapter presents the results of the study, including the identification of specific miRNAs dysregulated in different cancer types, their functional roles in cancer cell growth, migration, and invasion, and their potential as biomarkers for early cancer detection or prognostic prediction. The chapter also discusses the implications of these findings for cancer research and clinical practice. In conclusion, this thesis highlights the importance of miRNAs in cancer development and progression and underscores the need for further research to elucidate their roles in specific cancer types. The study contributes to the growing body of knowledge on miRNAs as key regulators of gene expression in cancer and suggests potential avenues for the development of novel diagnostic and therapeutic strategies targeting miRNAs. Overall, this thesis provides valuable insights into the role of miRNAs in cancer and opens new avenues for future research aimed at harnessing the potential of miRNAs for improved cancer diagnosis, prognosis, and treatment.

Thesis Overview

The project titled "Exploring the Role of MicroRNAs in Cancer Development and Progression" aims to investigate the involvement of microRNAs in the intricate process of cancer development and progression. MicroRNAs are small non-coding RNA molecules that play crucial roles in regulating gene expression at the post-transcriptional level. Dysregulation of microRNAs has been implicated in various diseases, including cancer, where they can act as oncogenes or tumor suppressors. The research will delve into the specific microRNAs that are known to be dysregulated in different types of cancer and explore their mechanisms of action in promoting or inhibiting cancer progression. By understanding how these microRNAs function in cancer cells, potential therapeutic targets may be identified for the development of novel treatment strategies. Additionally, the project will investigate the diagnostic and prognostic potential of microRNAs in cancer. MicroRNAs have been shown to have unique expression patterns in different cancer types, making them promising biomarkers for early detection and prognosis assessment. By analyzing the expression profiles of specific microRNAs in cancer patients, this research aims to contribute to the advancement of personalized medicine in oncology. Furthermore, the study will explore the interactions between microRNAs and key signaling pathways involved in cancer development, such as cell proliferation, apoptosis, and metastasis. By elucidating the crosstalk between microRNAs and these pathways, novel insights into the molecular mechanisms underlying cancer progression may be revealed. Overall, this research project seeks to provide a comprehensive overview of the role of microRNAs in cancer development and progression. By elucidating the complex interplay between microRNAs and cancer biology, this study aims to contribute to the growing body of knowledge in the field of oncology and pave the way for the development of innovative therapeutic approaches for cancer treatment.