Thesis Abstract

The abstract of this thesis focuses on investigating the role of microRNAs in cancer development and progression. MicroRNAs are small non-coding RNA molecules that play crucial roles in gene regulation. This research project aims to explore the involvement of microRNAs in cancer development and progression by examining their expression patterns, targets, and biological functions in various types of cancer. The introduction provides a background to the study, highlighting the significance of understanding the molecular mechanisms underlying cancer progression. The problem statement emphasizes the need to elucidate the specific roles of microRNAs in driving tumorigenesis and metastasis. The objectives of the study include identifying dysregulated microRNAs in different cancer types, elucidating their target genes, and investigating their impact on cancer cell behavior. The literature review synthesizes existing knowledge on microRNAs and cancer, covering topics such as the oncogenic and tumor-suppressive roles of specific microRNAs, the mechanisms of microRNA dysregulation in cancer, and the potential use of microRNAs as diagnostic and therapeutic targets. The research methodology section outlines the experimental approaches used to analyze microRNA expression, validate target genes, and assess the functional effects of specific microRNAs in cancer cells. The discussion of findings chapter presents the results of the study, including the identification of dysregulated microRNAs in different cancer types, the validation of target genes, and the functional characterization of specific microRNAs in promoting or inhibiting cancer progression. The conclusion summarizes the key findings of the study, discusses their implications for understanding cancer biology, and suggests future research directions in the field of microRNA-based cancer therapy. Overall, this thesis contributes to advancing our knowledge of the role of microRNAs in cancer development and progression, providing insights that may have implications for the development of novel diagnostic and therapeutic strategies for cancer treatment.

Thesis Overview

The project titled "Investigating the Role of MicroRNAs in Cancer Development and Progression" aims to explore the intricate involvement of microRNAs in the development and progression of cancer. Cancer is a complex and multifaceted disease characterized by uncontrolled cell growth and proliferation, leading to the formation of malignant tumors. MicroRNAs, small non-coding RNA molecules, have emerged as critical regulators of gene expression and play a significant role in various cellular processes, including cell differentiation, proliferation, and apoptosis. The research will delve into the specific mechanisms by which dysregulation of microRNAs contributes to the initiation and progression of cancer. By analyzing the expression profiles of microRNAs in different types of cancer tissues compared to normal tissues, the study aims to identify key microRNAs that are aberrantly expressed in cancer and may serve as potential biomarkers for diagnosis, prognosis, and therapeutic targets. Furthermore, the project will investigate the functional roles of these dysregulated microRNAs in promoting tumorigenesis, metastasis, and drug resistance in cancer cells. Understanding how microRNAs modulate key signaling pathways involved in cancer progression can provide valuable insights into the underlying molecular mechanisms driving the disease. Through a comprehensive literature review and experimental analysis, the research will aim to elucidate the intricate interplay between microRNAs and their target genes in cancer development. By deciphering the regulatory networks controlled by microRNAs, the study seeks to uncover novel therapeutic strategies that target specific microRNAs to inhibit tumor growth and improve patient outcomes. Overall, this project represents a significant contribution to the field of cancer research by shedding light on the critical role of microRNAs in cancer development and progression. The findings from this study have the potential to advance our understanding of cancer biology and pave the way for the development of innovative precision medicine approaches for the diagnosis and treatment of cancer.