Thesis Abstract

Abstract
MicroRNAs (miRNAs) are small non-coding RNA molecules that play crucial regulatory roles in various biological processes, including cancer development and progression. This thesis aims to explore the specific roles of miRNAs in cancer pathogenesis, with a focus on their involvement in tumor initiation, growth, metastasis, and therapeutic resistance. Through an extensive review of current literature and original research findings, this study sheds light on the intricate mechanisms by which miRNAs influence cancer biology. Chapter 1 provides a comprehensive introduction to the topic, presenting the background of the study, stating the problem statement, outlining the objectives, discussing the limitations and scope of the study, highlighting the significance of the research, and providing the structure of the thesis. Furthermore, definitions of key terms relevant to the study are elucidated to enhance understanding. Chapter 2 delves into a detailed literature review, examining ten key studies that investigate the roles of miRNAs in cancer development and progression. This section synthesizes existing knowledge and identifies research gaps that warrant further investigation. In Chapter 3, the research methodology is outlined, encompassing various aspects such as study design, sample collection, miRNA profiling techniques, bioinformatics analysis, and statistical methods. The methodology section provides a roadmap for conducting the research and ensures the reliability and validity of the findings. Chapter 4 presents a thorough discussion of the research findings, analyzing the roles of specific miRNAs in different types of cancer and elucidating their impact on key cancer hallmarks. The chapter also explores the clinical implications of miRNA dysregulation in cancer and discusses potential therapeutic strategies targeting miRNAs. Finally, Chapter 5 offers a comprehensive conclusion and summary of the thesis, highlighting the key findings, implications for future research, and potential clinical applications of miRNA-based therapies in cancer treatment. The study concludes by emphasizing the importance of understanding the roles of miRNAs in cancer development and progression for the advancement of personalized medicine and targeted cancer therapies. In conclusion, this thesis contributes to the growing body of knowledge on the role of miRNAs in cancer pathogenesis, providing insights that could lead to the development of novel diagnostic tools and therapeutic interventions for cancer patients. The research findings underscore the significance of miRNAs as promising biomarkers and therapeutic targets in the fight against cancer, paving the way for innovative approaches to cancer treatment and management.

Thesis Overview

The research project titled "Exploring the role of microRNAs in cancer development and progression" aims to investigate the intricate involvement of microRNAs in the processes of cancer development and progression. MicroRNAs are small non-coding RNAs that play crucial roles in regulating gene expression by targeting specific mRNA molecules for degradation or translational repression. In recent years, a growing body of evidence has highlighted the significant impact of dysregulated microRNA expression on cancer initiation, progression, and metastasis. The research will begin with a comprehensive review of the existing literature on microRNAs and their role in cancer biology. This literature review will encompass various aspects, including the biogenesis of microRNAs, their mechanisms of action, and the specific microRNAs implicated in different types of cancer. By synthesizing and analyzing this information, the study aims to provide a solid foundation for understanding the complex interplay between microRNAs and cancer. Following the literature review, the research will delve into the methodological approach adopted to investigate the role of microRNAs in cancer development and progression. This will involve the collection and analysis of biological samples, such as tumor tissues and blood samples, to profile microRNA expression patterns in cancer patients. Advanced molecular biology techniques, including quantitative real-time PCR and next-generation sequencing, will be employed to assess microRNA expression levels and identify potential biomarkers associated with cancer progression. The findings obtained from the experimental analyses will be discussed in detail in the subsequent chapters of the research. The research will explore how dysregulated microRNA expression profiles correlate with clinicopathological features, treatment outcomes, and patient survival in various types of cancer. Furthermore, the study will investigate the functional roles of specific microRNAs in cancer cell proliferation, migration, invasion, and apoptosis to unravel the underlying molecular mechanisms driving cancer progression. In conclusion, this research project aims to contribute valuable insights into the role of microRNAs in cancer development and progression. By elucidating the complex regulatory networks orchestrated by microRNAs in cancer cells, the study seeks to identify novel therapeutic targets and prognostic markers for improving cancer diagnosis and treatment strategies. Ultimately, the findings from this research have the potential to advance our understanding of cancer biology and pave the way for the development of innovative precision medicine approaches tailored to individual patients based on their microRNA expression profiles.