Thesis Abstract

Abstract
MicroRNAs (miRNAs) are small non-coding RNA molecules that play crucial roles in gene regulation and have emerged as key regulators in cancer development and progression. This thesis explores the intricate relationship between miRNAs and cancer, focusing on how these small RNA molecules influence various aspects of tumor growth, metastasis, and treatment resistance. Through an extensive literature review and original research, this study aims to provide a comprehensive understanding of the role of miRNAs in cancer biology. Chapter One introduces the topic by discussing the background of miRNAs and their involvement in cancer. The problem statement highlights the significance of studying miRNAs in cancer progression, while the objectives outline the specific goals of this research. The limitations and scope of the study are also described, along with the significance of the findings and the structure of the thesis. Chapter Two presents a detailed literature review covering ten key aspects of miRNAs in cancer, including their dysregulation in different cancer types, mechanisms of action, and potential as diagnostic and therapeutic targets. This chapter provides a comprehensive overview of the current knowledge on miRNAs and cancer, setting the stage for the subsequent research. Chapter Three outlines the research methodology employed in this study, detailing the experimental approaches and techniques used to investigate the role of miRNAs in cancer development and progression. This chapter includes information on sample collection, data analysis, and statistical methods to ensure the validity and reliability of the findings. Chapter Four presents the results and discussion of the research findings, highlighting the key miRNAs involved in cancer progression and their impact on tumor growth, metastasis, and treatment response. The data are analyzed in depth, and the implications of the findings are discussed in the context of existing literature and potential clinical applications. Chapter Five concludes the thesis by summarizing the key findings and their implications for understanding the role of miRNAs in cancer development and progression. The limitations of the study are acknowledged, and future research directions are proposed to further elucidate the complex interplay between miRNAs and cancer biology. In conclusion, this thesis provides a comprehensive analysis of the role of miRNAs in cancer development and progression, shedding light on the intricate molecular mechanisms underlying tumorigenesis and metastasis. The findings from this study contribute to the growing body of knowledge on miRNAs in cancer and may have important implications for the diagnosis, prognosis, and treatment of cancer patients.

Thesis Overview

The project titled "Exploring the Role of MicroRNAs in Cancer Development and Progression" aims to investigate the intricate involvement of microRNAs (miRNAs) in the development and progression of cancer. MicroRNAs are small non-coding RNA molecules that play crucial roles in gene regulation by targeting messenger RNA (mRNA) for degradation or translational repression. In recent years, miRNAs have emerged as key players in various biological processes, including carcinogenesis. The research will begin with a comprehensive literature review to provide a solid foundation for understanding the current knowledge surrounding miRNAs and cancer. This review will cover key studies and findings on the dysregulation of miRNAs in different types of cancer and their impact on cell proliferation, apoptosis, metastasis, and drug resistance. Moving forward, the project will delve into the methodology used to investigate miRNAs in cancer. This will include the collection and analysis of cancer samples, the identification of dysregulated miRNAs through high-throughput sequencing techniques, and the functional characterization of these miRNAs using in vitro and in vivo models. The findings obtained from the research will be thoroughly discussed in chapter four, highlighting the specific miRNAs implicated in cancer development and progression, their molecular mechanisms of action, and their potential as diagnostic or therapeutic targets. The discussion will also address the challenges and limitations encountered during the study and propose future directions for research in this field. Finally, the project will conclude with a summary of the key findings and their implications for cancer biology and clinical practice. The significance of the research in advancing our understanding of the role of miRNAs in cancer will be emphasized, along with the potential for developing novel miRNA-based strategies for cancer diagnosis and treatment. Overall, this research project aims to shed light on the complex interplay between miRNAs and cancer, paving the way for new insights and therapeutic opportunities in the fight against this devastating disease.