Thesis Abstract

Abstract
Cancer is a complex and heterogeneous disease that poses a significant challenge to global public health. MicroRNAs (miRNAs) have emerged as key regulators of gene expression and have been implicated in various aspects of cancer biology, including tumor initiation, progression, and response to therapy. This thesis aims to explore the role of miRNAs in cancer progression and their potential therapeutic applications. Chapter 1 provides an introduction to the research topic, presenting the background of the study, defining the problem statement, outlining the objectives, discussing the limitations and scope of the study, highlighting the significance of the research, and presenting the structure of the thesis. Chapter 1 also includes a definition of terms to establish a common understanding of key concepts related to miRNAs and cancer. Chapter 2 consists of a comprehensive literature review that explores existing research on miRNAs in cancer. This chapter covers various aspects of miRNA biology, their dysregulation in different cancer types, and their potential as diagnostic and therapeutic targets. The literature review synthesizes key findings from previous studies to provide a foundation for the current research. Chapter 3 details the research methodology employed in this study. It includes information on the study design, sample collection and analysis, experimental techniques, data interpretation methods, and statistical analysis. The methodology section outlines the steps taken to investigate the role of miRNAs in cancer progression and their potential therapeutic applications. Chapter 4 presents the findings of the study, discussing the role of specific miRNAs in different stages of cancer progression and their impact on cellular processes such as proliferation, migration, and apoptosis. This chapter also examines the potential therapeutic strategies targeting miRNAs for cancer treatment and provides insights into the mechanisms underlying their anti-cancer effects. Chapter 5 serves as the conclusion and summary of the thesis, highlighting the key findings, implications of the research, and recommendations for future studies. The conclusion section consolidates the main outcomes of the research and underscores the significance of understanding the role of miRNAs in cancer progression for the development of novel therapeutic approaches. In conclusion, this thesis sheds light on the intricate involvement of miRNAs in cancer progression and underscores their potential as valuable targets for cancer therapy. By elucidating the mechanisms through which miRNAs influence tumorigenesis and treatment response, this research contributes to the growing body of knowledge aimed at improving cancer diagnosis and management.

Thesis Overview

The project titled "Exploring the Role of MicroRNAs in Cancer Progression and Therapeutic Applications" aims to investigate the intricate involvement of microRNAs in the progression of cancer and explore their potential therapeutic applications. MicroRNAs are small non-coding RNA molecules that play crucial roles in post-transcriptional gene regulation. They have been implicated in various biological processes, including cell proliferation, differentiation, and apoptosis. In the context of cancer, dysregulation of microRNAs has been associated with tumor initiation, progression, and metastasis. The research will begin with a comprehensive review of the existing literature on microRNAs in cancer, highlighting key findings and gaps in knowledge. This literature review will provide a solid foundation for understanding the current state of research in this field and identify areas for further investigation. The project will then delve into the research methodology, outlining the experimental approaches and techniques that will be employed to study the role of specific microRNAs in cancer progression. This will involve in vitro and in vivo experiments using cancer cell lines and animal models to elucidate the mechanisms through which microRNAs modulate key pathways involved in tumor development and metastasis. The findings from these experiments will be presented and discussed in detail in the subsequent chapter. The discussion will focus on the implications of the results in the context of existing literature and the potential therapeutic applications of targeting specific microRNAs for cancer treatment. The project will also address the limitations of the study and suggest future directions for research in this area. In conclusion, this research project aims to contribute to the growing body of knowledge on the role of microRNAs in cancer progression and provide valuable insights into their therapeutic potential. By unraveling the complex interplay between microRNAs and cancer pathways, this study has the potential to pave the way for the development of novel targeted therapies for cancer patients.