Thesis Abstract

Abstract
Cancer is a complex disease characterized by uncontrolled cell growth that has a significant impact on global health. MicroRNAs (miRNAs) are small non-coding RNAs that play crucial roles in gene expression regulation and have been implicated in various biological processes, including cancer development and progression. This thesis aims to explore the role of miRNAs in cancer development and progression, focusing on their potential as diagnostic and therapeutic targets. Chapter One provides an introduction to the study, presenting the background of the research, problem statement, objectives, limitations, scope, significance, and structure of the thesis. Key terms relevant to the study are defined to establish a clear understanding of the research context. Chapter Two consists of an in-depth literature review that examines existing research on the role of miRNAs in cancer. The review covers ten key areas, including the biogenesis of miRNAs, their dysregulation in cancer, and their impact on cancer cell proliferation, invasion, and metastasis. Chapter Three outlines the research methodology employed in this study. It includes detailed descriptions of the study design, sample collection and processing, miRNA profiling techniques, data analysis methods, and statistical approaches. The chapter also discusses ethical considerations and quality control measures implemented throughout the research process. In Chapter Four, the findings of the study are comprehensively discussed. The results highlight specific miRNAs that are differentially expressed in various cancer types and their functional roles in cancer development and progression. The chapter also discusses the potential clinical implications of these findings and their relevance to cancer diagnosis, prognosis, and treatment. Chapter Five presents the conclusion and summary of the thesis, summarizing the key findings, discussing their implications, and suggesting future research directions. The study underscores the importance of miRNAs in cancer biology and emphasizes the potential of miRNAs as novel biomarkers and therapeutic targets in cancer management. In conclusion, this thesis contributes to the growing body of knowledge on the role of miRNAs in cancer development and progression. By elucidating the molecular mechanisms underlying miRNA dysregulation in cancer, this research provides valuable insights that could lead to the development of innovative diagnostic and therapeutic strategies for combating cancer.

Thesis Overview

The project titled "Exploring the Role of MicroRNAs in Cancer Development and Progression" aims to investigate the intricate involvement of microRNAs (miRNAs) in the development and progression of cancer. MicroRNAs are small non-coding RNA molecules that play a crucial role in regulating gene expression by targeting messenger RNA (mRNA) transcripts for degradation or translational repression. In recent years, accumulating evidence has highlighted the dysregulation of miRNAs in various types of cancer, suggesting their potential as diagnostic markers, prognostic indicators, and therapeutic targets. The research will delve into the specific miRNAs implicated in different stages of cancer development and progression, aiming to elucidate their molecular mechanisms and functional roles. By analyzing the expression profiles of miRNAs in cancer tissues compared to normal tissues, the study seeks to identify key miRNAs that are dysregulated in cancer and explore their downstream targets and biological pathways. Furthermore, the project will investigate the role of miRNAs in mediating crucial cellular processes such as cell proliferation, apoptosis, migration, and invasion, which are dysregulated in cancer cells. By understanding how miRNAs influence these processes, the research aims to provide insights into the underlying mechanisms driving cancer progression and metastasis. Moreover, the project will explore the potential of miRNAs as biomarkers for cancer diagnosis and prognosis. By correlating the expression levels of specific miRNAs with clinical parameters and patient outcomes, the study aims to assess the utility of miRNAs as predictive tools in cancer management. Overall, the research on "Exploring the Role of MicroRNAs in Cancer Development and Progression" seeks to advance our understanding of the complex interplay between miRNAs and cancer biology. By unraveling the molecular mechanisms by which miRNAs influence cancer development and progression, the study aims to contribute valuable insights that may lead to the development of novel diagnostic and therapeutic strategies for cancer patients.