Thesis Abstract

Abstract
This thesis investigates the intricate role of microRNAs in cancer progression and explores their potential therapeutic applications. The study delves into the molecular mechanisms underlying the dysregulation of microRNAs in cancer cells and how they contribute to tumor growth, metastasis, and drug resistance. Through an extensive literature review, the research highlights the significance of microRNAs as key regulators of gene expression and their involvement in various signaling pathways implicated in cancer development. The methodology section outlines the experimental approaches used to analyze microRNA expression profiles in different cancer types and elucidate their functional roles in tumorigenesis. Molecular biology techniques such as qRT-PCR, microarray analysis, and bioinformatics tools were employed to identify dysregulated microRNAs and their target genes in cancer cells. In addition, in vitro and in vivo studies were conducted to assess the impact of manipulating specific microRNAs on cancer cell behavior and response to therapy. The results section presents a detailed discussion of the findings, including the identification of key microRNAs associated with cancer progression and their potential as therapeutic targets. The research sheds light on the complex interplay between microRNAs and oncogenic pathways, highlighting their role in modulating cell proliferation, migration, and apoptosis. Furthermore, the study explores the emerging field of microRNA-based therapeutics, including the development of novel delivery strategies and combination therapies to enhance treatment efficacy. In conclusion, this thesis provides valuable insights into the role of microRNAs in cancer biology and their potential as diagnostic biomarkers and therapeutic targets. By elucidating the molecular mechanisms by which microRNAs influence cancer progression, this research contributes to the advancement of precision medicine approaches for cancer treatment. The findings presented in this study pave the way for future research aimed at harnessing the therapeutic potential of microRNAs in combating cancer and improving patient outcomes.

Thesis Overview

The project titled "Exploring the Role of MicroRNAs in Cancer Progression and Potential Therapeutic Applications" aims to delve into the intricate mechanisms by which microRNAs influence cancer progression and explore the promising therapeutic avenues that targeting these small non-coding RNAs may offer in the treatment of cancer. MicroRNAs are key regulators of gene expression, known to be dysregulated in various types of cancer, contributing to tumor initiation, progression, and metastasis. Understanding the specific roles of microRNAs in cancer biology can provide valuable insights into novel diagnostic and therapeutic strategies for combating cancer. This research project will start by providing a comprehensive overview of the current knowledge in the field of microRNAs and cancer, highlighting the importance of studying these small RNA molecules in the context of cancer progression. The project will then delve into the specific microRNAs that have been implicated in different types of cancer and their roles in regulating key pathways involved in tumor development and metastasis. Moreover, the project will investigate the potential therapeutic applications of targeting microRNAs in cancer treatment. By elucidating the mechanisms through which microRNAs modulate cancer progression, this research aims to identify novel therapeutic targets for the development of innovative cancer therapies. The project will explore the latest advances in microRNA-based therapeutics, including the use of synthetic microRNA mimics and inhibitors to modulate the expression of specific microRNAs in cancer cells. Through a combination of in vitro and in vivo experiments, this project seeks to validate the functional significance of specific microRNAs in cancer progression and evaluate the feasibility of targeting these microRNAs for therapeutic purposes. By elucidating the complex interplay between microRNAs and cancer biology, this research aims to contribute to the growing body of knowledge on the role of microRNAs in cancer and pave the way for the development of novel and effective therapeutic strategies for the treatment of cancer. Overall, this research project represents a significant step towards unraveling the intricate relationship between microRNAs and cancer progression, with the ultimate goal of harnessing the therapeutic potential of microRNAs for the development of precision cancer therapies.