Thesis Abstract

Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that play significant roles in regulating gene expression and have emerged as key players in cancer progression and treatment response. This thesis aims to explore the role of miRNAs in cancer by investigating their involvement in tumor development, metastasis, and response to various treatment modalities. The study encompasses a comprehensive literature review, research methodology, analysis of findings, and conclusion. Chapter One provides an introduction to the research topic, including background information on miRNAs, the problem statement, objectives of the study, limitations, scope, significance, structure of the thesis, and definition of terms. Chapter Two presents a detailed literature review covering ten key aspects related to miRNAs in cancer progression and treatment response. The review synthesizes existing knowledge on the role of miRNAs in different types of cancer, their dysregulation mechanisms, and their potential as diagnostic and therapeutic targets. Chapter Three outlines the research methodology employed in this study, including the selection of miRNAs of interest, experimental techniques used for miRNA profiling, data analysis methods, and validation strategies. The chapter also discusses the ethical considerations and challenges encountered during the research process. In Chapter Four, the findings of the study are elaborated, focusing on the differential expression of miRNAs in cancer tissues compared to normal tissues, correlations between miRNA expression levels and clinical outcomes, and the impact of miRNA modulation on cancer cell behavior and response to therapy. The chapter presents a detailed discussion of the results, highlighting the potential implications for cancer diagnosis, prognosis, and treatment strategies. Finally, Chapter Five offers a conclusion and summary of the thesis, emphasizing the key findings, their significance in the field of cancer research, and potential future directions. The study contributes to the growing body of knowledge on the role of miRNAs in cancer progression and treatment response, providing insights that may guide the development of novel therapeutic approaches and personalized medicine strategies. In conclusion, this thesis sheds light on the complex interplay between miRNAs and cancer biology, highlighting their potential as biomarkers and therapeutic targets in the fight against cancer. The findings underscore the importance of further research in this area to fully elucidate the molecular mechanisms underlying miRNA-mediated effects on cancer progression and treatment response.

Thesis Overview

The project titled "Exploring the Role of MicroRNAs in Cancer Progression and Treatment Response" aims to investigate the intricate involvement of microRNAs in the progression of cancer and the response to various treatment modalities. MicroRNAs, small non-coding RNA molecules, have emerged as crucial regulators of gene expression and play significant roles in various cellular processes, including cell proliferation, differentiation, and apoptosis. In cancer, dysregulation of microRNAs has been implicated in tumorigenesis, metastasis, and resistance to therapy, making them attractive targets for understanding and potentially modulating cancer behavior. The research will delve into the specific microRNAs that are dysregulated in different types of cancer and explore their functional significance in promoting or inhibiting cancer progression. By elucidating the molecular mechanisms through which these microRNAs exert their effects on cancer cells, the study aims to provide valuable insights into the underlying biology of cancer and potential therapeutic targets. Furthermore, the project will investigate how microRNAs influence the response of cancer cells to various treatment strategies, including chemotherapy, targeted therapy, and immunotherapy. Understanding the interplay between microRNAs and treatment response could help identify novel predictive biomarkers for treatment efficacy and guide the development of more personalized and effective cancer therapies. Overall, this research project seeks to contribute to the growing body of knowledge on the role of microRNAs in cancer biology and therapy, with the ultimate goal of advancing our understanding of cancer progression and improving treatment outcomes for cancer patients.