Thesis Abstract

Abstract
The dysregulation of microRNAs (miRNAs) has been implicated in various cancer types, affecting key cellular processes involved in cancer progression. This thesis aims to explore the role of miRNAs in cancer progression and investigate their potential implications for therapeutic interventions. The research is structured into five chapters to comprehensively address the research objectives. Chapter 1 provides an introduction to the study, outlining the background, problem statement, objectives, limitations, scope, significance, structure of the thesis, and definition of terms. The introduction emphasizes the importance of understanding miRNAs in cancer biology and highlights the need for targeted therapeutic approaches. Chapter 2 presents a comprehensive literature review consisting of ten key items. This review synthesizes existing knowledge on miRNAs in cancer progression, highlighting their regulatory functions in various signaling pathways and their impact on tumor development and metastasis. The literature review sets the stage for the subsequent research methodology. Chapter 3 details the research methodology with a focus on miRNA profiling, cell culture experiments, and bioinformatics analysis. The methodology section outlines the experimental design, sample collection, RNA extraction, miRNA expression analysis, and statistical methods employed to investigate the role of miRNAs in cancer progression. Chapter 4 presents an elaborate discussion of the research findings, including the identification of dysregulated miRNAs in cancer cells, their target genes, and functional implications in cancer progression. The discussion section integrates experimental results with existing literature to elucidate the mechanisms through which miRNAs modulate cancer phenotypes. Chapter 5 concludes the thesis by summarizing the key findings, discussing their implications for cancer therapy, and suggesting future research directions. The conclusion highlights the potential of miRNAs as therapeutic targets in cancer treatment and emphasizes the importance of personalized medicine approaches to exploit the regulatory functions of miRNAs in cancer progression. In conclusion, this thesis contributes to the understanding of the role of miRNAs in cancer progression and provides insights into their potential implications for therapeutic interventions. The findings underscore the importance of miRNAs as key regulators of cancer biology and support the development of novel targeted therapies for improving cancer treatment outcomes.

Thesis Overview