1. Introduction
  1.1 Background and significance
  1.2 Objectives of the study
2. Drug metabolism in prostate cancer
  2.1 Role of drug-metabolizing enzymes
  2.2 Altered drug metabolism in prostate cancer
3. Drug-metabolizing enzymes in prostate cancer
  3.1 Cytochrome P450 enzymes
  3.2 UDP-glucuronosyltransferases
  3.3 Glutathione S-transferases
4. Impact of altered drug metabolism on drug efficacy and toxicity
  4.1 Drug response in prostate cancer
  4.2 Drug toxicity in prostate cancer
5. Experimental methods
  5.1 Cell culture and treatment
  5.2 Expression analysis of drug-metabolizing enzymes
  5.3 Enzyme activity assays