Exploring the biochemistry of drug metabolism in breast cancer
Table Of Contents
<p>1. Introduction<br> 1.1 Background and significance<br> 1.2 Objectives of the study<br>2. Drug metabolism in breast cancer<br> 2.1 Role of drug-metabolizing enzymes<br> 2.2 Altered drug metabolism in breast cancer<br>3. Drug-metabolizing enzymes in breast cancer<br> 3.1 Cytochrome P450 enzymes<br> 3.2 UDP-glucuronosyltransferases<br> 3.3 Glutathione S-transferases<br>4. Impact of altered drug metabolism on drug response<br> 4.1 Drug efficacy in breast cancer<br> 4.2 Drug toxicity in breast cancer<br>5. Experimental methods<br> 5.1 Cell culture and treatment<br> 5.2 Expression analysis of drug-metabolizing enzymes<br> 5.3 Enzyme activity assays<br></p>
Thesis Abstract
<p> Breast cancer is a heterogeneous disease with varying responses to anticancer drugs, and drug metabolism plays a crucial role in determining treatment outcomes. This project aims to explore the biochemistry of drug metabolism in breast cancer. By investigating the expression and activity of drug-metabolizing enzymes in breast cancer cells, as well as the impact of altered drug metabolism on drug response, this research will contribute to a better understanding of the molecular mechanisms underlying drug metabolism in breast cancer. <br></p>Thesis Overview
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