Investigating the biochemistry of drug metabolism in liver cancer
Table Of Contents
1. Introduction
1.1 Background and significance
1.2 Objectives of the study
2. Drug metabolism in liver cancer
2.1 Role of drug-metabolizing enzymes
2.2 Altered drug metabolism in liver cancer
3. Drug-metabolizing enzymes in liver cancer
3.1 Cytochrome P450 enzymes
3.2 UDP-glucuronosyltransferases
3.3 Glutathione S-transferases
4. Impact of altered drug metabolism on drug response
4.1 Drug efficacy in liver cancer
4.2 Drug toxicity in liver cancer
5. Experimental methods
5.1 Cell culture and treatment
5.2 Expression analysis of drug-metabolizing enzymes
5.3 Enzyme activity assays
Thesis Abstract
Liver cancer is a major global health concern, and drug metabolism plays a crucial role in the efficacy and toxicity of anticancer drugs. This project aims to investigate the biochemistry of drug metabolism in liver cancer. By studying the expression and activity of drug-metabolizing enzymes in liver cancer cells, as well as the impact of altered drug metabolism on drug response, this research will contribute to a better understanding of the molecular mechanisms underlying drug metabolism in liver cancer.
Thesis Overview
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