1. Introduction
1.1 Background and significance
1.2 Objectives of the study
2. DNA damage and repair mechanisms
2.1 Types of DNA damage
2.2 DNA repair pathways
3. Role of DNA damage in cardiovascular diseases
3.1 DNA damage markers in cardiovascular diseases
3.2 Impact of DNA damage on cardiovascular cells
4. DNA repair pathways in cardiovascular diseases
4.1 Base excision repair
4.2 Nucleotide excision repair
4.3 Homologous recombination
4.4 Non-homologous end joining
5. Experimental methods
5.1 Cell culture and treatment
5.2 DNA damage assessment techniques
5.3 DNA repair assays
Cardiovascular diseases, including heart disease and stroke, are leading causes of death worldwide. The underlying mechanisms of these diseases involve DNA damage and impaired DNA repair processes. This project aims to investigate the biochemistry of DNA damage and repair in cardiovascular diseases. By studying the specific DNA repair pathways involved and the impact of DNA damage on cardiovascular cells, this research will contribute to a better understanding of the molecular mechanisms underlying cardiovascular diseases.
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