1. Introduction
  1.1 Background and rationale
  1.2 Objectives of the study
2. Cartilage structure and function
  2.1 Overview of cartilage tissue
  2.2 Role of cartilage in drug distribution and metabolism
  2.3 Biochemical processes involved in drug metabolism in the cartilage
3. Enzymatic pathways in cartilage drug metabolism
  3.1 Overview of cartilage-specific enzymes
  3.2 Expression and activity of enzymes involved in cartilage drug metabolism
  3.3 Impact of enzymatic pathways on drug metabolism in the cartilage
4. Drug transporters in cartilage tissue
  4.1 Overview of drug transporters in cartilage
  4.2 Expression and function of drug transporters in cartilage tissue
  4.3 Role of drug transporters in drug distribution and metabolism in the cartilage
5. Impact of cartilage metabolism on drug pharmacokinetics
  5.1 Absorption, distribution, metabolism, and excretion (ADME) of drugs in cartilage tissue
  5.2 Influence of cartilage metabolism on drug bioavailability and clearance
  5.3 Implications for drug efficacy and toxicity