<p>1.Introduction 1.1 Background<br> 1.2 Objectives<br>2. DNA damage and genomic instability in cancer<br> 2.1 Types of DNA damage<br> 2.2 Sources of DNA damage in cancer<br> 2.3 Impact of DNA damage on genomic integrity<br>3. DNA repair pathways in cancer<br> 3.1 Base excision repair (BER)<br> 3.2 Nucleotide excision repair (NER)<br> 3.3 Mismatch repair (MMR)<br> 3.4 Homologous recombination (HR)<br> 3.5 Non-homologous end joining (NHEJ)<br>4. Interplay between DNA repair and cancer progression<br> 4.1 DNA repair gene mutations in cancer<br> 4.2 DNA repair and resistance to therapy<br> 4.3 DNA repair as a therapeutic target<br>5. Emerging strategies for targeting DNA repair in cancer<br> 5.1 PARP inhibitors<br> 5.2 DNA repair gene targeting<br> 5.3 Combination therapies involving DNA repair inhibitors<br></p>
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