1. Introduction
1.1 Background
1.2 Objectives
2. Physicochemical properties of drugs
2.1 Drug solubility and dissolution
2.2 Drug stability and degradation
2.3 Drug permeability and absorption
3. Formulation strategies for drug delivery
3.1 Nanoparticles and nanocarriers
3.2 Liposomes and lipid-based formulations
3.3 Controlled-release systems
4. Drug-excipient interactions
4.1 Role of excipients in drug formulation
4.2 Excipient-drug compatibility and stability
4.3 Excipient-mediated drug release
5. Factors influencing drug bioavailability
5.1 Physiological barriers to drug absorption
5.2 Drug metabolism and elimination
5.3 Drug-drug interactions
The formulation and delivery of drugs play a crucial role in their efficacy and safety. The biochemistry of drug formulation and delivery involves understanding the physicochemical properties of drugs, their interactions with excipients, and the mechanisms of drug release and absorption in the body. This project aims to explore the biochemistry of drug formulation and delivery by investigating various formulation strategies, such as nanoparticles, liposomes, and controlled-release systems. Additionally, the project will examine the factors influencing drug stability, solubility, and bioavailability. The findings from this study will contribute to the development of improved drug delivery systems and enhance the understanding of the biochemistry behind their effectiveness.
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