Project Abstract

This project aims to investigate the alarming issue of antimicrobial resistance (AMR) at the human-animal interface. Companion animals, such as dogs and cats, are increasingly recognized as potential reservoirs and vectors of drug-resistant bacteria, posing a significant threat to public health. The close and intimate relationship between these animals and their owners amplifies the potential for the transmission of resistant microorganisms, with serious implications for both human and animal health. The project will focus on assessing and comparing the prevalence and patterns of antimicrobial resistance in companion animals and their owners. By conducting a comprehensive, cross-sectional study, the research team will collect samples from both the animals and their corresponding human caregivers, and analyze the isolates for the presence of antibiotic-resistant bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae, and other clinically relevant resistant pathogens. The significance of this project lies in its potential to provide crucial insights into the complex dynamics of AMR transmission between companion animals and their owners. The findings will have far-reaching implications for public health policy, veterinary and human healthcare practices, and the development of effective infection control strategies. By employing state-of-the-art molecular techniques, the study will not only identify the prevalence of resistant bacteria but also characterize the genetic mechanisms and clonal relatedness of the isolates recovered from both human and animal samples. This comprehensive approach will enable the research team to unravel the patterns of AMR dissemination and potentially trace the directionality of transmission between the two populations. Moreover, the project will explore the role of various risk factors, such as antimicrobial use, hygiene practices, and pet-keeping behaviors, in shaping the AMR landscape within the human-animal interface. The findings will inform the development of targeted interventions and educational campaigns to promote responsible antimicrobial use, enhance biosecurity measures, and foster a deeper understanding of the One Health approach to tackling the global AMR crisis. The project's interdisciplinary nature, involving experts from the fields of veterinary medicine, public health, and molecular epidemiology, will ensure a holistic and evidence-based approach to addressing this pressing concern. The collaborative efforts will contribute to the development of innovative strategies to mitigate the spread of antimicrobial resistance, safeguarding the health and well-being of both humans and their beloved companion animals. In conclusion, this project represents a crucial step towards understanding the complex interplay between AMR in companion animals and their owners. By elucidating the patterns and drivers of resistance, the research team aims to inform evidence-based policies, enhance clinical practices, and empower both veterinary and human healthcare professionals to combat the growing threat of antimicrobial resistance at the human-animal interface.

Project Overview