The study is aimed at determining the impact of motivation on employee’s job performance in the Nigeria public service. (A case study of NAFDAC). The purpose is to investigate and identify factors responsible for the current state of affairs and seek to find practical solution for lack of staff motivation and job performance. The research design is survey research design comprising of opinions, impressions and perceptions of the respondents. The sampling techniques were simple random sampling and proportionate stratified random sampling. In sampling opinion to collect data, the questionnaire was used. In all, a population of 30 staff of NAFDAC comprising top management, middle management and junior staff were administered to them but only 20 responded comprising 13 male and 7females. The result from the test of the hypothesis indicated that commensurate salaries and allowance paid to employee of NAFDAC would motivate them towards higher job performance.