Project Abstract

This project aims to investigate the complex mechanisms underlying the regulation of cardiac function during exercise, a critical physiological process that enables the heart to meet the increased demands of the body during physical activity. Understanding the intricacies of this regulation is crucial for maintaining cardiovascular health, optimizing athletic performance, and developing effective strategies for the prevention and management of exercise-related cardiovascular disorders. During exercise, the cardiovascular system undergoes significant changes to ensure that the body's tissues receive an adequate supply of oxygenated blood. The heart, as the central organ of the cardiovascular system, must adapt to these increased demands by adjusting its contractile force, heart rate, and overall efficiency. This project will explore the various neurohormonal, autonomic, and intrinsic factors that contribute to the regulation of cardiac function during different intensities and durations of exercise. One key aspect of the project will focus on the role of the autonomic nervous system in modulating cardiac performance. The sympathetic and parasympathetic branches of the autonomic nervous system work in a coordinated manner to control heart rate, contractility, and vascular tone, thereby influencing the heart's ability to meet the body's metabolic needs during exercise. The project will investigate how the balance between these two branches shifts in response to the changing demands of physical activity and how this affects cardiac output and blood flow distribution. Another area of investigation will be the influence of circulating hormones, such as catecholamines and thyroid hormones, on cardiac function during exercise. These hormones can directly and indirectly affect the heart's contractility, heart rate, and overall efficiency, and their interactions with the autonomic nervous system will be explored. Furthermore, the project will examine the intrinsic mechanisms within the heart that contribute to the regulation of cardiac function during exercise. This includes the role of cardiac muscle cells (cardiomyocytes) and their response to increased workload, as well as the involvement of regulatory proteins and signaling pathways that modulate the heart's contractile properties. By employing a combination of experimental techniques, including in vivo animal studies, human clinical trials, and computational modeling, this project aims to provide a comprehensive understanding of the multi-faceted regulatory mechanisms that enable the heart to adapt to the demands of exercise. The findings from this research will have far-reaching implications, including the potential development of targeted interventions to enhance cardiovascular performance in athletes, as well as the identification of novel therapeutic approaches for individuals with exercise-related cardiovascular disorders. In conclusion, this project on the regulation of cardiac function during exercise is a crucial endeavor that will advance our knowledge of the complex physiological processes underlying the heart's ability to meet the increased demands of physical activity. The insights gained from this research will contribute to the promotion of cardiovascular health and the optimization of exercise performance, ultimately benefiting individuals across a wide range of physical activity levels and health conditions.

Project Overview