<p> </p><p>

Chapter ONE

</p><p>1.0 &nbsp; &nbsp; Introduction</p><p>1.1 &nbsp; &nbsp; Fibrinogen</p><p>1.1.1 Fibrinogen Synthesis</p><p>1.1.2 Functions of Fibrinogen</p><p>

Chapter TWO

</p><p>2.0 &nbsp; &nbsp; Types of fibrinogen disorders</p><p>2.1 &nbsp; &nbsp; Clinical manifestations</p><p>2.1.1 Hypofibrinogenemia</p><p>2.1.2 Dysfibrinogenemia</p><p>2.2 &nbsp; &nbsp; Laboratory diagnosis</p><p>2.2.1 Molecular diagnosis</p><p>2.2.2 Dysfibrinogenemia mutations</p><p>2.2.3 Prenatal diagnosis</p><p>

Chapter THREE

</p><p>3.0 &nbsp; &nbsp; Fibrinogen Replacement</p><p>3.1 &nbsp; &nbsp; Fresh Frozen Plasma</p><p>3.2 &nbsp; &nbsp; Cryoprecipitate</p><p>3.3 &nbsp; &nbsp; Fibrinogen Concentrate</p><p>3.4 &nbsp; &nbsp; Current understanding of fibrinogen replacement</p><p>3.4.1 Preclinical Data</p><p>3.4.2 Clinical Data</p><p>3.4.2.1 Trauma</p><p>3.4.2.2 Perioperative Bleeding</p><p>

Chapter FOUR

</p><p>4.0 &nbsp; &nbsp; Conclusion and Recommendation</p><p>4.1 &nbsp; &nbsp; Conclusion</p><p>4.2 &nbsp; &nbsp; Recommendation</p><p>References.</p> <br><p></p>