<p> </p><p>

Chapter ONE

</p><p>1.0 &nbsp; &nbsp; Introduction</p><p>1.1 &nbsp; &nbsp; History</p><p>1.2 &nbsp; &nbsp; Aetiology</p><p>

Chapter TWO

</p><p>2.0 &nbsp; &nbsp; Literature Review</p><p>2.1 &nbsp; &nbsp; Typical crisis bleeding in Hemophilia</p><p>2.1.1 Hemarthrosis</p><p>2.1.2 Hematoma</p><p>2.1.3 Hematuria</p><p>2.1.4 Gastrointestinal (GI) Bleeding</p><p>2.1.5 Laceration</p><p>2.1.6 Head Trauma</p><p>2.1.7 Emergency Care</p><p>2.1.8 Assessment of the need for treatment</p><p>

Chapter THREE

</p><p>3.0 &nbsp; &nbsp; Inhibitors of factors VIII or factor IX</p><p>3.1 &nbsp; &nbsp; Options for the therapy of factor VIII deficiency</p><p>3.2 &nbsp; &nbsp; Options for the therapy of factor IX deficiency</p><p>3.3 &nbsp; &nbsp; Recombinant versus plasma derived factor VIII</p><p>

Chapter FOUR

</p><p>4.0 &nbsp; &nbsp; Management</p><p>4.1 &nbsp; &nbsp; Medical Consideration of Patient Family Members</p><p>4.1.1 Prophylaxis</p><p>4.1.2 Gene Therapy</p><p>References</p> <br><p></p>