Phytochemical analysis and the anti-inflammatory activities of dichloromethane fraction of methhanol extract of crateva adansonii
Table Of Contents
Chapter ONE
1.1 Introduction1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Research
1.9 Definition of Terms
Chapter TWO
2.1 Overview of Phytochemicals2.2 Phytochemical Analysis Methods
2.3 Anti-Inflammatory Agents in Plants
2.4 Previous Studies on Crateva Adansonii
2.5 Phytochemical Composition of Crateva Adansonii
2.6 Anti-Inflammatory Properties of Crateva Adansonii
2.7 Comparison with Other Plant Extracts
2.8 Mechanisms of Action of Phytochemicals
2.9 Role of Dichloromethane Fraction in Inflammation
2.10 Importance of Studying Phytochemicals
Chapter THREE
3.1 Research Design3.2 Sampling Method
3.3 Data Collection Techniques
3.4 Experimental Setup
3.5 Data Analysis Procedures
3.6 Ethical Considerations
3.7 Validity and Reliability
3.8 Statistical Tools
Chapter FOUR
4.1 Analysis of Phytochemical Composition4.2 Evaluation of Anti-Inflammatory Activities
4.3 Comparison with Standard Drugs
4.4 Dosage Optimization
4.5 Toxicity Studies
4.6 Mechanistic Insights
4.7 Clinical Trials
4.8 Future Research Directions
Chapter FIVE
5.1 Summary of Findings5.2 Conclusion
5.3 Recommendations
5.4 Implications for Future Research
5.5 Contribution to Knowledge
Project Abstract
Inflammation is a complex biological response of vascular tissue to harmful stimuli such as pathogen, damage cells or irritants (Ryan & Majno, 1983). The urgency generated by increased rate of stroke, atherosclerosis attribute due to prolonged use of cyclooxygenase-1 and Cyclooxygenase- 2 inhibitors have accelerated anti-inflammatory drug research over the last decade while synthetic pharmaceutical agents continued to dominate research (Ryan & Majno, 1983). Attention increasingly has been directed to natural products. These are often more affordable and available and sometimes are perceived as more effective than conventional anti- inflammatory drugs.
Anti-inflammation was carried out using 12 rats which was divided into three groups of 4 rats each. Group 1 and 2 served as the negative and positive control respectively. Group 3 received 25mg/kg b.w. of the dichloromethane fraction of methanol extract of Crateva adansonii showed significance anti-inflammatory activity when compared with the standard difference used.
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