Phytochemical analysis and the anti-inflammatory activities of dichloromethane fraction of methhanol extract of crateva adansonii
Table Of Contents
Chapter ONE
1.1 Introduction 1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Research
1.9 Definition of Terms
Chapter TWO
2.1 Overview of Phytochemicals 2.2 Importance of Phytochemical Analysis
2.3 Anti-Inflammatory Properties of Plants
2.4 Crateva Adansonii: Botanical Description
2.5 Phytochemical Composition of Crateva Adansonii
2.6 Previous Studies on Crateva Adansonii
2.7 Dichloromethane Fraction Extraction
2.8 Methanol Extraction Process
2.9 Understanding Anti-Inflammatory Activities
2.10 Mechanisms of Action of Phytochemicals
Chapter THREE
3.1 Research Methodology Overview 3.2 Selection of Crateva Adansonii Samples
3.3 Phytochemical Extraction Procedures
3.4 Isolation of Dichloromethane Fraction
3.5 In vitro Anti-Inflammatory Assays
3.6 Data Collection Methods
3.7 Statistical Analysis Techniques
3.8 Ethical Considerations
Chapter FOUR
4.1 Analysis of Phytochemical Components 4.2 Evaluation of Anti-Inflammatory Effects
4.3 Comparison with Existing Literature
4.4 Interpretation of Results
4.5 Discussion on Mechanisms of Action
4.6 Implications for Future Research
4.7 Addressing Limitations
4.8 Recommendations for Further Studies
Chapter FIVE
5.1 Conclusion and Summary 5.2 Recap of Research Objectives
5.3 Key Findings Recap
5.4 Contributions to Scientific Knowledge
5.5 Practical Applications
5.6 Future Research Directions
Project Abstract
Inflammation is a complex biological response of vascular tissue to harmful stimuli such as pathogen, damage cells or irritants (Ryan & Majno, 1983). The urgency generated by increased rate of stroke, atherosclerosis attribute due to prolonged use of cyclooxygenase-1 and Cyclooxygenase- 2 inhibitors have accelerated anti-inflammatory drug research over the last decade while synthetic pharmaceutical agents continued to dominate research (Ryan & Majno, 1983). Attention increasingly has been directed to natural products. These are often more affordable and available and sometimes are perceived as more effective than conventional anti- inflammatory drugs.
Anti-inflammation was carried out using 12 rats which was divided into three groups of 4 rats each. Group 1 and 2 served as the negative and positive control respectively. Group 3 received 25mg/kg b.w. of the dichloromethane fraction of methanol extract of Crateva adansonii showed significance anti-inflammatory activity when compared with the standard difference used.
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