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Study on the effect of allium ascalonicum ethanolic extract on liver functions: asp, alt, ast, direct and total bilirubin in adult wistar rats

 

Table Of Contents


Chapter ONE

1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Research
1.9 Definition of Terms

Chapter TWO

2.1 Overview of Liver Functions
2.2 Allium Ascalonicum - Botanical Description
2.3 Liver Function Tests
2.4 Previous Studies on Allium Ascalonicum
2.5 Mechanism of Action of Allium Ascalonicum Extract
2.6 Liver Function Biomarkers
2.7 Effects of Allium Ascalonicum Extract on Liver Enzymes
2.8 Allium Ascalonicum Extract and Bilirubin Levels
2.9 Interaction of Allium Ascalonicum with Liver Functions
2.10 Summary of Literature Review

Chapter THREE

3.1 Research Design and Methodology
3.2 Selection of Sample Population
3.3 Preparation of Allium Ascalonicum Ethanolic Extract
3.4 Animal Model Establishment
3.5 Administration of Allium Ascalonicum Extract
3.6 Liver Function Tests Protocol
3.7 Data Collection Methods
3.8 Statistical Analysis Plan

Chapter FOUR

4.1 Analysis of Liver Function Test Results
4.2 Effect of Allium Ascalonicum Extract on AST Levels
4.3 Effect of Allium Ascalonicum Extract on ALT Levels
4.4 Effect of Allium Ascalonicum Extract on Bilirubin Levels
4.5 Comparison of Liver Function Test Results
4.6 Interpretation of Findings
4.7 Discussion on the Mechanism of Action
4.8 Implications and Further Research

Chapter FIVE

5.1 Summary of Findings
5.2 Conclusion
5.3 Recommendations for Future Research
5.4 Practical Implications
5.5 Contribution to Existing Knowledge
5.6 Limitations of the Study
5.7 Research Contribution to Scientific Community
5.8 Final Remarks and Acknowledgments

Project Abstract

The effect of ethanolic extract of Allium Ascallonicum was evaluated in male and female wistar rat during 14 days after the doses of (300, 500, 700)mg/kg body weight orally. Parameter evaluated include serum ASP, AST, ALT, direct bilirubin and Total bilirubin.20 wistar rats were divided into four groups with weight range of (150±20)g the group 1 is the control group ,group(ii,iii,iv) are treated with the extract in varying concentration of (300,500,700)mg/kg body weight respectively. The result showed that the groups treated with A. ascalonicum insignificantly increased in AST, ALT and ALP parameter by (p>0.05) and insignificant decreased in direct and total bilirubin parameter by (p>0.05).

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