Thesis Abstract

Abstract
The rise of antibiotic-resistant bacteria poses a significant threat to public health worldwide, necessitating the exploration of alternative treatment strategies. Bacteriophages, or viruses that infect and kill bacteria, have emerged as a promising avenue for combating antibiotic-resistant bacterial infections. This thesis delves into the role of bacteriophages in controlling antibiotic-resistant bacteria, examining their potential as a novel therapeutic approach. Chapter 1 provides a comprehensive introduction to the research topic, presenting the background of the study, the problem statement, research objectives, limitations, scope, significance, and the structure of the thesis. Additionally, key terminologies relevant to the study are defined to establish a common understanding. Chapter 2 consists of a detailed literature review, encompassing ten critical aspects related to bacteriophages, antibiotic resistance, and their potential synergy in combatting bacterial infections. The review synthesizes existing knowledge and gaps in the field, setting the foundation for the subsequent research methodology. Chapter 3 elucidates the research methodology employed in this study, encompassing eight key components such as study design, sampling techniques, data collection methods, and data analysis procedures. The methodology aims to provide a robust framework for investigating the role of bacteriophages in controlling antibiotic-resistant bacteria. Chapter 4 presents an in-depth discussion of the findings obtained through the research process. The chapter analyzes the efficacy of bacteriophages in targeting and eradicating antibiotic-resistant bacteria, exploring factors influencing their success as a potential treatment option. Furthermore, the chapter discusses the implications of the findings within the broader context of antimicrobial resistance. In Chapter 5, the thesis concludes with a summary of key findings and insights derived from the study. The conclusion reflects on the significance of bacteriophages in combating antibiotic-resistant bacteria and offers recommendations for future research directions. Overall, this thesis contributes to the growing body of knowledge on the role of bacteriophages as a promising strategy in addressing the global challenge of antibiotic resistance. Keywords bacteriophages, antibiotic-resistant bacteria, phage therapy, antimicrobial resistance, alternative treatment strategies.

Thesis Overview

The project titled "Exploring the role of bacteriophages in controlling antibiotic-resistant bacteria" aims to investigate the potential of bacteriophages as a novel strategy to combat antibiotic-resistant bacteria. Antibiotic resistance has become a global health crisis, leading to treatment failures and increased mortality rates. Bacteriophages, or phages, are viruses that specifically target and infect bacteria, offering a promising alternative to traditional antibiotics. The research will begin with a comprehensive literature review to establish the current understanding of bacteriophages and antibiotic resistance. This will include an examination of the mechanisms of antibiotic resistance, the challenges associated with current treatment options, and the history and potential applications of phage therapy. The methodology section will outline the experimental approach to evaluate the effectiveness of bacteriophages against antibiotic-resistant bacteria. This will involve identifying and isolating specific phages that target resistant strains, characterizing their activity, and assessing their ability to reduce bacterial growth in vitro and in vivo. The discussion of findings will present the results of the experiments, including the efficacy of phages in controlling antibiotic-resistant bacteria, any limitations encountered during the study, and the implications of the findings for future research and clinical applications. Potential challenges and ethical considerations related to phage therapy will also be addressed. In conclusion, this research aims to contribute to the growing body of knowledge on phage therapy as a potential solution to the problem of antibiotic resistance. By exploring the role of bacteriophages in controlling antibiotic-resistant bacteria, this project seeks to provide insights that could lead to the development of alternative treatments and help address the urgent need for new antimicrobial strategies in the face of rising resistance levels.