Thesis Abstract

Abstract
Antibiotic resistance is a growing concern in healthcare settings worldwide, leading to an urgent need for alternative strategies to combat drug-resistant bacterial infections. Bacteriophages, viruses that infect and kill bacteria, have emerged as a promising option for controlling antibiotic-resistant bacteria. This thesis explores the potential role of bacteriophages in addressing the challenge of antibiotic resistance in clinical settings. Chapter 1 provides an introduction to the topic, discussing the background of the study, problem statement, objectives, limitations, scope, significance, structure of the thesis, and definitions of key terms. The literature review in Chapter 2 examines existing research on bacteriophages and their use in controlling antibiotic-resistant bacteria, including their mechanisms of action, advantages, limitations, and current applications. Chapter 3 outlines the research methodology, including the selection of bacteriophages, bacterial strains, experimental design, data collection methods, and data analysis techniques. The chapter also discusses ethical considerations and potential challenges in conducting research on bacteriophages. Chapter 4 presents a detailed discussion of the research findings, including the efficacy of bacteriophages in controlling antibiotic-resistant bacteria, factors influencing their effectiveness, potential risks, and future research directions. The chapter also compares the use of bacteriophages with traditional antibiotics and highlights the potential of phage therapy in clinical practice. In Chapter 5, the conclusion and summary of the thesis are provided, summarizing the key findings, implications for clinical practice, and recommendations for future research. The thesis concludes that bacteriophages show promise as a viable alternative to antibiotics for controlling antibiotic-resistant bacteria in clinical settings, with the potential to address the global challenge of antibiotic resistance. Overall, this thesis contributes to the understanding of bacteriophages as a potential solution to antibiotic resistance and highlights the importance of further research and development in this area to advance phage therapy as a promising strategy in clinical practice.

Thesis Overview

The project titled "Exploring the role of bacteriophages in controlling antibiotic-resistant bacteria in clinical settings" aims to investigate the potential of bacteriophages as a novel strategy to combat antibiotic-resistant bacteria in clinical settings. Antibiotic resistance is a growing global health threat, leading to increased morbidity, mortality, and healthcare costs. Bacteriophages are viruses that specifically target and infect bacteria, offering a promising alternative or adjunct to traditional antibiotics. The research will begin with a comprehensive literature review to provide a background on antibiotic resistance, the mechanisms of bacteriophages, and their potential applications in clinical settings. This review will explore previous studies, current trends, and gaps in knowledge to establish a foundation for the research. The methodology section will outline the experimental design, including the selection of bacteriophages, antibiotic-resistant bacteria strains, and in vitro or in vivo models for testing. Various parameters such as phage-bacteria interactions, host range, efficacy, and safety profiles will be evaluated to assess the potential of bacteriophages in controlling antibiotic-resistant bacteria. The findings discussion will present the results of the experiments, including the effectiveness of bacteriophages in targeting and killing antibiotic-resistant bacteria. Factors influencing phage therapy success, such as bacterial resistance mechanisms and phage-host compatibility, will be analyzed to understand the underlying dynamics. The conclusion will summarize the key findings, implications, and limitations of the research. It will also provide recommendations for further studies and potential applications of bacteriophages in clinical practice to combat antibiotic resistance. Overall, this research project aims to contribute to the growing body of knowledge on bacteriophages as a potential solution to the global challenge of antibiotic resistance in clinical settings. By exploring the role of bacteriophages in controlling antibiotic-resistant bacteria, this study seeks to provide insights that may lead to the development of innovative and effective therapeutic strategies for combating drug-resistant infections.