Thesis Abstract

Abstract
With the rise of antibiotic-resistant bacterial infections posing a significant global health threat, alternative strategies are urgently needed to combat this challenge. Bacteriophages, viruses that specifically target and infect bacteria, have emerged as a promising alternative to antibiotics. This thesis aims to explore the potential of bacteriophages in treating antibiotic-resistant bacterial infections and to assess their effectiveness, safety, and practicality as therapeutic agents. The research begins with a comprehensive review of the literature on bacteriophages, antibiotics, antibiotic resistance, and the current state of bacterial infections worldwide. The review highlights the limitations of antibiotics, the mechanisms of antibiotic resistance, and the advantages of bacteriophages as potential alternatives. The methodology chapter outlines the research design, experimental procedures, and data analysis methods used in this study. Various bacteriophage isolates will be obtained and characterized for their specificity and effectiveness against antibiotic-resistant bacterial strains. In vitro and in vivo experiments will be conducted to evaluate the therapeutic potential of bacteriophages in treating antibiotic-resistant infections. The findings chapter presents the results of the experiments, including the efficacy of bacteriophages in targeting and killing antibiotic-resistant bacteria, the potential development of resistance to bacteriophages, and any observed side effects or limitations of bacteriophage therapy. The discussion chapter critically analyzes the implications of the findings, compares bacteriophages to antibiotics, and discusses the challenges and opportunities in implementing bacteriophage therapy in clinical settings. In conclusion, this thesis underscores the importance of exploring bacteriophages as alternatives to antibiotics in combating antibiotic-resistant bacterial infections. The results suggest that bacteriophages hold promise as effective and safe therapeutic agents, with the potential to address the growing threat of antibiotic resistance. Further research and clinical trials are warranted to fully harness the therapeutic potential of bacteriophages and pave the way for their integration into mainstream medical practice. Keywords Bacteriophages, Antibiotics, Antibiotic Resistance, Bacterial Infections, Therapeutic Agents, Alternative Treatments, Experimental Studies, Clinical Trials

Thesis Overview