Thesis Abstract

Abstract
Osteoarthritis is a chronic degenerative joint disease that affects both humans and animals, including dogs. Current treatment options for osteoarthritis in dogs are limited and often focus on managing symptoms rather than providing a cure. Stem cell therapy has emerged as a promising regenerative medicine approach for treating osteoarthritis by promoting tissue repair and reducing inflammation. This thesis explores the use of stem cell therapy in treating osteoarthritis in dogs, aiming to evaluate its effectiveness and safety in improving the quality of life for canine patients. The introduction provides an overview of osteoarthritis in dogs, discussing its prevalence, etiology, and impact on canine health and mobility. The background of the study delves into the pathophysiology of osteoarthritis, highlighting the role of inflammation, cartilage degradation, and joint stiffness in disease progression. The problem statement underscores the limitations of current treatment modalities and the need for more effective and long-lasting therapeutic options for managing osteoarthritis in dogs. The objectives of the study include investigating the mechanisms of action of stem cell therapy in promoting joint repair and reducing inflammation, assessing the safety and efficacy of stem cell treatment in dogs with osteoarthritis, and determining the long-term effects of stem cell therapy on canine mobility and pain management. The scope of the study focuses on evaluating the outcomes of stem cell therapy in a cohort of dogs diagnosed with osteoarthritis, utilizing a combination of clinical assessments, imaging studies, and patient-reported outcomes. The significance of the study lies in its potential to advance the field of veterinary regenerative medicine by providing valuable insights into the therapeutic benefits of stem cell therapy for osteoarthritis in dogs. The thesis structure outlines the organization of the research work, including the methodology, literature review, discussion of findings, and conclusion. The literature review synthesizes existing knowledge on stem cell therapy for osteoarthritis in dogs, analyzing previous studies, clinical trials, and case reports to build a comprehensive understanding of the current state of research in this field. The research methodology details the study design, participant selection criteria, stem cell isolation and administration protocols, outcome measures, and statistical analysis methods employed in the investigation. The discussion of findings presents the results of the study, including improvements in joint function, pain reduction, and overall quality of life observed in dogs treated with stem cell therapy. The analysis of data highlights the positive outcomes and potential challenges associated with stem cell treatment for osteoarthritis in dogs, offering insights into the feasibility and applicability of this regenerative approach in veterinary clinical practice. In conclusion, this thesis demonstrates the efficacy and safety of stem cell therapy in treating osteoarthritis in dogs, providing a foundation for further research and clinical trials in this promising field of veterinary medicine. The findings support the use of stem cell therapy as a viable and innovative treatment option for alleviating pain, improving mobility, and enhancing the well-being of canine patients with osteoarthritis.

Thesis Overview

The research project titled "Exploring the Use of Stem Cell Therapy in Treating Osteoarthritis in Dogs" aims to investigate the potential benefits and effectiveness of utilizing stem cell therapy as a treatment modality for osteoarthritis in dogs. Osteoarthritis is a common degenerative joint disease in canines, causing pain, stiffness, and reduced mobility, significantly impacting their quality of life. Traditional treatment options for osteoarthritis in dogs include medication, physical therapy, and surgery, but these may only provide symptomatic relief and not address the underlying cause of the disease. Stem cell therapy has emerged as a promising alternative approach in veterinary medicine for managing osteoarthritis. Stem cells possess unique regenerative properties that can potentially repair damaged tissues, reduce inflammation, and promote tissue regeneration. By harnessing the regenerative potential of stem cells, this research aims to explore how stem cell therapy can help alleviate the symptoms of osteoarthritis in dogs and potentially slow down disease progression. The research will involve conducting a thorough literature review to examine existing studies, clinical trials, and case reports on the use of stem cell therapy for treating osteoarthritis in dogs. This review will help establish the current understanding of stem cell therapy in veterinary medicine and identify gaps in knowledge that warrant further investigation. Furthermore, the research methodology will involve designing and conducting controlled experiments or clinical trials to evaluate the safety, efficacy, and long-term outcomes of stem cell therapy in dogs with osteoarthritis. Parameters such as pain scores, joint function, radiographic imaging, and biomarkers will be used to assess the therapeutic effects of stem cell treatment and compare them to conventional therapies. The findings of this research project are expected to contribute valuable insights into the potential benefits of stem cell therapy for managing osteoarthritis in dogs. By elucidating the mechanisms of action, safety profile, and clinical outcomes of stem cell therapy, this research aims to provide evidence-based recommendations for veterinarians and pet owners considering this innovative treatment option for their canine companions. In conclusion, "Exploring the Use of Stem Cell Therapy in Treating Osteoarthritis in Dogs" represents a significant step towards advancing the field of regenerative medicine in veterinary care. By investigating the therapeutic potential of stem cells in addressing osteoarthritis, this research seeks to improve the well-being and quality of life of dogs suffering from this debilitating condition.