Thesis Abstract

Abstract
Osteoarthritis is a common degenerative joint disease affecting both humans and animals, including dogs, causing pain and reduced mobility. Traditional treatments for osteoarthritis in dogs have limitations, prompting the exploration of alternative therapies. Stem cell therapy has emerged as a promising approach for treating osteoarthritis, harnessing the regenerative potential of stem cells to repair damaged joint tissues. This thesis aims to explore the use of stem cell therapy in treating osteoarthritis in dogs, assessing its efficacy, safety, and potential benefits. Chapter One provides an introduction to the research topic, presenting the background of the study, problem statement, objectives, limitations, scope, significance, structure of the thesis, and definition of terms. The literature review in Chapter Two examines existing research on stem cell therapy for osteoarthritis in dogs, highlighting key findings, challenges, and gaps in knowledge. Chapter Three details the research methodology, including the study design, sample selection, stem cell administration protocols, outcome measures, data analysis, and ethical considerations. In Chapter Four, the discussion of findings delves into the results of the study, evaluating the effectiveness of stem cell therapy in treating osteoarthritis in dogs based on clinical outcomes, biomarkers, imaging studies, and owner assessments. The discussion also explores potential mechanisms of action, safety considerations, and implications for future research and clinical practice. Finally, Chapter Five presents the conclusion and summary of the thesis, summarizing key findings, discussing the implications for veterinary medicine, and suggesting recommendations for further research and clinical application of stem cell therapy for osteoarthritis in dogs. Overall, this thesis contributes to the growing body of knowledge on stem cell therapy for osteoarthritis in dogs, offering insights into its potential as a novel treatment modality. The findings from this study may inform veterinary practitioners and researchers, guiding the development of improved therapeutic strategies for managing osteoarthritis in canine patients and enhancing their quality of life.

Thesis Overview

The research project titled "Exploring the Use of Stem Cell Therapy in Treating Osteoarthritis in Dogs" aims to investigate the potential benefits and effectiveness of utilizing stem cell therapy as a treatment option for osteoarthritis in dogs. Osteoarthritis, a degenerative joint disease, is a common condition in aging dogs that leads to pain, stiffness, and decreased mobility. Current treatment options for osteoarthritis in dogs include pain management, anti-inflammatory medications, physical therapy, and surgery. However, these treatments may only provide temporary relief or have limitations in addressing the underlying cause of the disease. Stem cell therapy has gained attention in veterinary medicine as a promising regenerative treatment approach for various conditions, including osteoarthritis. Stem cells have the unique ability to differentiate into different cell types and promote tissue repair and regeneration. By harnessing the regenerative potential of stem cells, this therapy aims to not only alleviate symptoms but also repair damaged joint tissues, slow down disease progression, and improve the overall quality of life for dogs with osteoarthritis. The research will involve a comprehensive literature review to examine existing studies, clinical trials, and case reports on the use of stem cell therapy in treating osteoarthritis in dogs. This review will explore the mechanisms of action of stem cells in joint repair, the types of stem cells used, treatment protocols, outcomes, and potential risks or limitations associated with the therapy. By synthesizing the available evidence, the study aims to provide a thorough understanding of the current state of knowledge regarding stem cell therapy for canine osteoarthritis. Furthermore, the research project will include a detailed methodology section outlining the experimental design, inclusion criteria for study subjects, stem cell isolation and administration protocols, outcome measures, and data analysis methods. The study will aim to conduct a clinical trial or observational study to evaluate the efficacy and safety of stem cell therapy in a cohort of dogs diagnosed with osteoarthritis. Objective assessments such as gait analysis, pain scoring, radiographic imaging, and owner-reported outcomes will be used to measure the treatment effects. The findings of this research will contribute valuable insights into the potential role of stem cell therapy in managing osteoarthritis in dogs and may pave the way for future advancements in regenerative medicine for companion animals. By elucidating the mechanisms of action and therapeutic benefits of stem cells, this study seeks to provide evidence-based recommendations for veterinarians and pet owners considering alternative treatments for canine osteoarthritis. Ultimately, the goal of this project is to improve the welfare and quality of life for dogs suffering from this debilitating joint disease.