Thesis Abstract

Abstract
Canine osteoarthritis is a common degenerative joint disease that affects a large population of dogs worldwide, leading to pain, reduced mobility, and impaired quality of life. Traditional treatments for osteoarthritis in dogs often focus on managing symptoms rather than addressing the underlying cause of the disease. Stem cell therapy has emerged as a promising regenerative medicine approach that aims to promote tissue repair and regeneration in osteoarthritic joints. This thesis explores the use of stem cell therapy in treating canine osteoarthritis, focusing on its mechanisms of action, efficacy, safety, and potential applications in veterinary medicine. Chapter 1 provides an introduction to the research topic, presenting the background of the study, problem statement, objectives, limitations, scope, significance, structure of the thesis, and definition of key terms. The literature review in Chapter 2 critically examines existing research on stem cell therapy for osteoarthritis in dogs, highlighting key findings, challenges, and gaps in knowledge. Chapter 3 details the research methodology employed in this study, including the selection of study subjects, stem cell isolation and culture techniques, treatment protocols, outcome measures, and data analysis methods. The results of the study are presented and discussed in Chapter 4, focusing on the effects of stem cell therapy on clinical signs, joint function, imaging findings, and histological changes in osteoarthritic joints of canine patients. The findings of this research contribute to the growing body of evidence supporting the use of stem cell therapy as a promising treatment modality for canine osteoarthritis. The conclusion in Chapter 5 summarizes the key findings of the study, discusses their implications for veterinary practice, and offers recommendations for future research directions in the field of regenerative medicine for companion animals. Overall, this thesis sheds light on the potential of stem cell therapy to revolutionize the management of canine osteoarthritis, offering new hope for improving the health and well-being of dogs suffering from this debilitating condition.

Thesis Overview

Overview: The project titled "Exploring the Use of Stem Cell Therapy in Treating Canine Osteoarthritis" aims to investigate the potential benefits and effectiveness of utilizing stem cell therapy as a treatment modality for canine osteoarthritis. Osteoarthritis is a common degenerative joint disease in dogs, characterized by progressive deterioration of joint cartilage, leading to pain, stiffness, and reduced mobility. Current treatment options for canine osteoarthritis are limited and often focus on managing symptoms rather than addressing the underlying cause of the disease. Stem cell therapy has emerged as a promising regenerative medicine approach that holds potential for repairing damaged joint tissues and promoting long-term joint health. The research will begin with a comprehensive literature review to explore the existing knowledge and research findings related to stem cell therapy for osteoarthritis in dogs. This review will encompass studies on the use of different types of stem cells, such as mesenchymal stem cells, in promoting cartilage repair and reducing inflammation in arthritic joints. By synthesizing and analyzing the current body of literature, the research aims to establish a solid foundation for the subsequent phases of the study. The methodology section of the research will detail the experimental design and approach used to investigate the efficacy of stem cell therapy in treating canine osteoarthritis. This will include the selection of appropriate canine models of osteoarthritis, the isolation and characterization of stem cells, the administration of stem cell therapy, and the evaluation of treatment outcomes through various clinical, radiographic, and histological measures. The research will also address ethical considerations and animal welfare guidelines to ensure the humane conduct of the study. The findings and discussion section will present the results of the study, including the effects of stem cell therapy on joint function, pain relief, cartilage regeneration, and overall quality of life in dogs with osteoarthritis. The research will analyze and interpret the data obtained from the study to evaluate the therapeutic potential of stem cell therapy in treating canine osteoarthritis. Additionally, the discussion will explore the mechanisms of action underlying the observed effects of stem cell therapy and compare them with conventional treatment modalities. In conclusion, the project aims to contribute valuable insights into the use of stem cell therapy as a novel and effective treatment option for canine osteoarthritis. By elucidating the therapeutic mechanisms and potential benefits of stem cell therapy, the research seeks to pave the way for the development of innovative regenerative medicine strategies that can improve the management and outcomes of osteoarthritis in dogs.